Metabolic engineering for the production of plant isoquinoline alkaloids
A Diamond, I Desgagné‐Penix - Plant biotechnology journal, 2016 - Wiley Online Library
Several plant isoquinoline alkaloids (PIA s) possess powerful pharmaceutical and
biotechnological properties. Thus, PIA metabolism and its fascinating molecules, including …
biotechnological properties. Thus, PIA metabolism and its fascinating molecules, including …
Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research
Plants produce a variety of secondary metabolites that possess strong physiological
activities. Unfortunately, however, their production can suffer from a variety of serious …
activities. Unfortunately, however, their production can suffer from a variety of serious …
Recent progress in the metabolic engineering of alkaloids in plant systems
WS Glenn, W Runguphan, SE O'Connor - Current opinion in biotechnology, 2013 - Elsevier
Plant alkaloids have a rich chemical ecology that has been exploited for medicinal purposes
for thousands of years. Despite being highly represented within today's pharmacopoeia …
for thousands of years. Despite being highly represented within today's pharmacopoeia …
Fermentative production of plant benzylisoquinoline alkaloids in microbes
H Minami - Bioscience, Biotechnology, and Biochemistry, 2013 - Taylor & Francis
Higher plants produce diverse chemicals, including alkaloids, terpenoids, and phenolic
compounds (phenylpropanoids and flavonoids) as secondary metabolites. These chemicals …
compounds (phenylpropanoids and flavonoids) as secondary metabolites. These chemicals …
Metabolic engineering of plants for alkaloid production
EH Hughes, JV Shanks - Metabolic Engineering, 2002 - Elsevier
Alkaloids purified from plants provide many pharmacologically active compounds, including
leading chemotherapy drugs. As is generally true of secondary metabolites, overall …
leading chemotherapy drugs. As is generally true of secondary metabolites, overall …
Metabolic engineering in isoquinoline alkaloid biosynthesis
F Sato, T Inui, T Takemura - Current Pharmaceutical …, 2007 - ingentaconnect.com
Higher plants produce diverse classes of metabolites. Metabolic engineering offers
tremendous potential to improve the production and quality of these chemicals. This report …
tremendous potential to improve the production and quality of these chemicals. This report …
Medicinally important secondary metabolites in recombinant microorganisms or plants: progress in alkaloid biosynthesis
H Schäfer, M Wink - Biotechnology Journal: Healthcare …, 2009 - Wiley Online Library
Plants produce a high diversity of natural products or secondary metabolites which are
important for the communication of plants with other organisms. A prominent function is the …
important for the communication of plants with other organisms. A prominent function is the …
Present status of Catharanthus roseus monoterpenoid indole alkaloids engineering in homo- and hetero-logous systems
Catharanthus roseus synthesizes one of the most structurally, chemically and biologically
active phytomolecules monoterpenoids indole alkaloids (MIAs) with having a wide range of …
active phytomolecules monoterpenoids indole alkaloids (MIAs) with having a wide range of …
Metabolic engineering of cell cultures versus whole plant complexity in production of bioactive monoterpene indole alkaloids: recent progress related to old dilemma
G Pasquali, DD Porto, AG Fett-Neto - Journal of Bioscience and …, 2006 - Elsevier
Monoterpene indole alkaloids (MIAs) are a large class of plant alkaloids with significant
pharmacological interest. The sustained production of MIAs at high yields is an important …
pharmacological interest. The sustained production of MIAs at high yields is an important …
Evolutionary and cellular webs in benzylisoquinoline alkaloid biosynthesis
DK Liscombe, PJ Facchini - Current Opinion in Biotechnology, 2008 - Elsevier
Alkaloids are a group of approximately 12000 low molecular weight and nitrogenous
secondary metabolites found in 20% of plant species. Their potent biological activity …
secondary metabolites found in 20% of plant species. Their potent biological activity …