Metabolic engineering for the production of plant isoquinoline alkaloids

A Diamond, I Desgagné‐Penix - Plant biotechnology journal, 2016 - Wiley Online Library
Several plant isoquinoline alkaloids (PIA s) possess powerful pharmaceutical and
biotechnological properties. Thus, PIA metabolism and its fascinating molecules, including …

Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research

F Sato, H Kumagai - Proceedings of the Japan Academy, Series B, 2013 - jstage.jst.go.jp
Plants produce a variety of secondary metabolites that possess strong physiological
activities. Unfortunately, however, their production can suffer from a variety of serious …

Recent progress in the metabolic engineering of alkaloids in plant systems

WS Glenn, W Runguphan, SE O'Connor - Current opinion in biotechnology, 2013 - Elsevier
Plant alkaloids have a rich chemical ecology that has been exploited for medicinal purposes
for thousands of years. Despite being highly represented within today's pharmacopoeia …

Fermentative production of plant benzylisoquinoline alkaloids in microbes

H Minami - Bioscience, Biotechnology, and Biochemistry, 2013 - Taylor & Francis
Higher plants produce diverse chemicals, including alkaloids, terpenoids, and phenolic
compounds (phenylpropanoids and flavonoids) as secondary metabolites. These chemicals …

Metabolic engineering of plants for alkaloid production

EH Hughes, JV Shanks - Metabolic Engineering, 2002 - Elsevier
Alkaloids purified from plants provide many pharmacologically active compounds, including
leading chemotherapy drugs. As is generally true of secondary metabolites, overall …

Metabolic engineering in isoquinoline alkaloid biosynthesis

F Sato, T Inui, T Takemura - Current Pharmaceutical …, 2007 - ingentaconnect.com
Higher plants produce diverse classes of metabolites. Metabolic engineering offers
tremendous potential to improve the production and quality of these chemicals. This report …

Medicinally important secondary metabolites in recombinant microorganisms or plants: progress in alkaloid biosynthesis

H Schäfer, M Wink - Biotechnology Journal: Healthcare …, 2009 - Wiley Online Library
Plants produce a high diversity of natural products or secondary metabolites which are
important for the communication of plants with other organisms. A prominent function is the …

Present status of Catharanthus roseus monoterpenoid indole alkaloids engineering in homo- and hetero-logous systems

A Sharma, D Amin, A Sankaranarayanan, R Arora… - Biotechnology …, 2020 - Springer
Catharanthus roseus synthesizes one of the most structurally, chemically and biologically
active phytomolecules monoterpenoids indole alkaloids (MIAs) with having a wide range of …

Metabolic engineering of cell cultures versus whole plant complexity in production of bioactive monoterpene indole alkaloids: recent progress related to old dilemma

G Pasquali, DD Porto, AG Fett-Neto - Journal of Bioscience and …, 2006 - Elsevier
Monoterpene indole alkaloids (MIAs) are a large class of plant alkaloids with significant
pharmacological interest. The sustained production of MIAs at high yields is an important …

Evolutionary and cellular webs in benzylisoquinoline alkaloid biosynthesis

DK Liscombe, PJ Facchini - Current Opinion in Biotechnology, 2008 - Elsevier
Alkaloids are a group of approximately 12000 low molecular weight and nitrogenous
secondary metabolites found in 20% of plant species. Their potent biological activity …