Diversity in chemical structures and biological properties of plant alkaloids

S Bhambhani, KR Kondhare, AP Giri - Molecules, 2021 - mdpi.com
Phytochemicals belonging to the group of alkaloids are signature specialized metabolites
endowed with countless biological activities. Plants are armored with these naturally …

Establishment of a co-culture system using Escherichia coli and Pichia pastoris (Komagataella phaffii) for valuable alkaloid production

M Urui, Y Yamada, Y Ikeda, A Nakagawa, F Sato… - Microbial Cell …, 2021 - Springer
Background Plants produce a variety of specialized metabolites, many of which are used in
pharmaceutical industries as raw materials. However, certain metabolites may be produced …

Biosynthesis of quinolizidine alkaloids in lupins: mechanistic considerations and prospects for pathway elucidation

D Mancinotti, KM Frick, F Geu-Flores - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2022 Quinolizidine alkaloids (QAs) are a class of alkaloids that accumulate
in a variety of leguminous plants and have applications in the agricultural, pharmaceutical …

Redirecting tropane alkaloid metabolism reveals pyrrolidine alkaloid diversity in Atropa belladonna

HM Parks, MA Cinelli, MA Bedewitz, JM Grabar… - New …, 2023 - Wiley Online Library
Plant‐specialized metabolism is complex, with frequent examples of highly branched
biosynthetic pathways, and shared chemical intermediates. As such, many plant‐specialized …

A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis

RS Nett, Y Dho, YY Low… - Proceedings of the …, 2021 - National Acad Sciences
Plants synthesize many diverse small molecules that affect function of the mammalian
central nervous system, making them crucial sources of therapeutics for neurological …

Engineering Catharanthus roseus monoterpenoid indole alkaloid pathway in yeast

V Mistry, S Darji, P Tiwari, A Sharma - Applied microbiology and …, 2022 - Springer
Catharanthus roseus (Madagascar periwinkle), a medicinal plant possessing high
pharmacological attributes, is widely recognized for the biosynthesis of anticancer …

Reconstitution of monoterpene indole alkaloid biosynthesis in genome engineered Nicotiana benthamiana

QM Dudley, S Jo, DAS Guerrero, M Chhetry… - Communications …, 2022 - nature.com
Monoterpene indole alkaloids (MIAs) are a diverse class of plant natural products that
include a number of medicinally important compounds. We set out to reconstitute the …

Biochemical genomics for gene discovery in benzylisoquinoline alkaloid biosynthesis in opium poppy and related species

TTT Dang, A Onoyovwi, SC Farrow, PJ Facchini - Methods in enzymology, 2012 - Elsevier
Benzylisoquinoline alkaloids (BIAs) are a large, diverse group of∼ 2500 specialized plant
metabolites. Many BIAs display potent pharmacological activities, including the narcotic …

Production and metabolic engineering of terpenoid indole alkaloids in cell cultures of the medicinal plant Catharanthus roseus (L.) G. Don (Madagascar periwinkle)

ML Zhou, JR Shao, YX Tang - Biotechnology and applied …, 2009 - Wiley Online Library
The Madagascar periwinkle [Catharanthus roseus (L.) G. Don] is a plant species known for
its production of TIAs (terpenoid indole alkaloids), many of which are pharmaceutically …

[HTML][HTML] Cytochrome P450 enzymes as key drivers of alkaloid chemical diversification in plants

TD Nguyen, TTT Dang - Frontiers in Plant Science, 2021 - frontiersin.org
Plants produce more than 20,000 nitrogen-containing heterocyclic metabolites called
alkaloids. These chemicals serve numerous eco-physiological functions in the plants as well …