Diversity in chemical structures and biological properties of plant alkaloids
S Bhambhani, KR Kondhare, AP Giri - Molecules, 2021 - mdpi.com
Phytochemicals belonging to the group of alkaloids are signature specialized metabolites
endowed with countless biological activities. Plants are armored with these naturally …
endowed with countless biological activities. Plants are armored with these naturally …
Establishment of a co-culture system using Escherichia coli and Pichia pastoris (Komagataella phaffii) for valuable alkaloid production
M Urui, Y Yamada, Y Ikeda, A Nakagawa, F Sato… - Microbial Cell …, 2021 - Springer
Background Plants produce a variety of specialized metabolites, many of which are used in
pharmaceutical industries as raw materials. However, certain metabolites may be produced …
pharmaceutical industries as raw materials. However, certain metabolites may be produced …
Biosynthesis of quinolizidine alkaloids in lupins: mechanistic considerations and prospects for pathway elucidation
D Mancinotti, KM Frick, F Geu-Flores - Natural Product Reports, 2022 - pubs.rsc.org
Covering: up to 2022 Quinolizidine alkaloids (QAs) are a class of alkaloids that accumulate
in a variety of leguminous plants and have applications in the agricultural, pharmaceutical …
in a variety of leguminous plants and have applications in the agricultural, pharmaceutical …
Redirecting tropane alkaloid metabolism reveals pyrrolidine alkaloid diversity in Atropa belladonna
HM Parks, MA Cinelli, MA Bedewitz, JM Grabar… - New …, 2023 - Wiley Online Library
Plant‐specialized metabolism is complex, with frequent examples of highly branched
biosynthetic pathways, and shared chemical intermediates. As such, many plant‐specialized …
biosynthetic pathways, and shared chemical intermediates. As such, many plant‐specialized …
A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis
Plants synthesize many diverse small molecules that affect function of the mammalian
central nervous system, making them crucial sources of therapeutics for neurological …
central nervous system, making them crucial sources of therapeutics for neurological …
Engineering Catharanthus roseus monoterpenoid indole alkaloid pathway in yeast
Catharanthus roseus (Madagascar periwinkle), a medicinal plant possessing high
pharmacological attributes, is widely recognized for the biosynthesis of anticancer …
pharmacological attributes, is widely recognized for the biosynthesis of anticancer …
Reconstitution of monoterpene indole alkaloid biosynthesis in genome engineered Nicotiana benthamiana
QM Dudley, S Jo, DAS Guerrero, M Chhetry… - Communications …, 2022 - nature.com
Monoterpene indole alkaloids (MIAs) are a diverse class of plant natural products that
include a number of medicinally important compounds. We set out to reconstitute the …
include a number of medicinally important compounds. We set out to reconstitute the …
Biochemical genomics for gene discovery in benzylisoquinoline alkaloid biosynthesis in opium poppy and related species
Benzylisoquinoline alkaloids (BIAs) are a large, diverse group of∼ 2500 specialized plant
metabolites. Many BIAs display potent pharmacological activities, including the narcotic …
metabolites. Many BIAs display potent pharmacological activities, including the narcotic …
Production and metabolic engineering of terpenoid indole alkaloids in cell cultures of the medicinal plant Catharanthus roseus (L.) G. Don (Madagascar periwinkle)
ML Zhou, JR Shao, YX Tang - Biotechnology and applied …, 2009 - Wiley Online Library
The Madagascar periwinkle [Catharanthus roseus (L.) G. Don] is a plant species known for
its production of TIAs (terpenoid indole alkaloids), many of which are pharmaceutically …
its production of TIAs (terpenoid indole alkaloids), many of which are pharmaceutically …
[HTML][HTML] Cytochrome P450 enzymes as key drivers of alkaloid chemical diversification in plants
Plants produce more than 20,000 nitrogen-containing heterocyclic metabolites called
alkaloids. These chemicals serve numerous eco-physiological functions in the plants as well …
alkaloids. These chemicals serve numerous eco-physiological functions in the plants as well …