The accumulation of amyloid-β-containing neuritic plaques and intracellular tau protein
tangles are key histopathological hallmarks of Alzheimer's disease (AD). This type of …

Beclin 1 is a protein involved in the regulation of autophagy and has been shown to be
reduced in patients with Alzheimer disease. This review summarizes the current research …

Autophagy is an intracellular degradation pathway that functions in protein and organelle
turnover in response to starvation and cellular stress. Autophagy is initiated by the formation …

Autophagy is the principal cellular pathway for degradation of long-lived proteins and
organelles and regulates cell fate in response to stress. Recently, autophagy has been …

Phagocytosis controls CNS homeostasis by facilitating the removal of unwanted cellular
debris. Accordingly, impairments in different receptors or proteins involved in phagocytosis …

The Beclin-1 protein is essential for the initiation of autophagy, and recent studies suggest
this function may be compromised in Alzheimer's disease (AD). In addition, in vitro studies …

Impairment of the autophagy pathway has been observed during the pathogenesis of
Alzheimer's disease (AD), a neurodegenerative disorder characterized by abnormal …

Beclin 1, the mammalian orthologue of yeast Atg6, has a central role in autophagy, a
process of programmed cell survival, which is increased during periods of cell stress and …

Beclin 1 a yeast Atg6/VPS30 orthologue has a significant role in autophagy process
(Macroautophagy) and protein sorting. The function of beclin 1 depends on the interaction …

Beclin 1 is the first mammalian autophagy protein identified as a novel Bcl-2-interacting
protein. Subsequent studies have demonstrated that this landmark protein is essential for …