Regulation of the mRNA-binding protein HuR by posttranslational modification: spotlight on phosphorylation

W Eberhardt, A Doller… - Current Protein and …, 2012 - ingentaconnect.com
The ubiquitous mRNA-binding protein human antigen R (HuR) and its neuronal relatives
(HuB, HuC, HuD) participate in the post-transcriptional regulation of many AU-rich element …

Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR

A Doller, J Pfeilschifter, W Eberhardt - Cellular signalling, 2008 - Elsevier
During the last decade evidence from numerous studies has been accumulated
demonstrating that posttranscriptional gene regulation including mRNA turnover and …

[HTML][HTML] Adaptive and maladaptive expression of the mRNA regulatory protein HuR

S Govindaraju, BS Lee - World journal of biological chemistry, 2013 - ncbi.nlm.nih.gov
The RNA-binding proteins involved in regulation of mRNA post-transcriptional processing
and translation control the fates of thousands of mRNA transcripts and basic cellular …

Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR

S Schulz, A Doller, NR Pendini, JA Wilce, J Pfeilschifter… - Cellular signalling, 2013 - Elsevier
The ubiquitous mRNA binding protein human antigen R (HuR) participates in the post-
transcriptional regulation of many AU-rich element (ARE)-bearing mRNAs. Previously, by …

Posttranslational control of HuR function

I Grammatikakis, K Abdelmohsen… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
The RNA‐binding protein HuR (human antigen R) associates with numerous transcripts,
coding and noncoding, and controls their splicing, localization, stability, and translation …

RNA-binding protein HuR autoregulates its expression by promoting alternative polyadenylation site usage

W Dai, G Zhang, EV Makeyev - Nucleic acids research, 2012 - academic.oup.com
RNA-binding protein HuR modulates the stability and translational efficiency of messenger
RNAs (mRNAs) encoding essential components of the cellular proliferation, growth and …

HuR: post-transcriptional paths to malignancy

IL Silanes, A Lal, M Gorospe - RNA biology, 2005 - Taylor & Francis
The RNA-binding protein HuR regulates the stability and translation of target mRNAs. While
no HuR mutations have been found in cancer, a link between HuR and malignant …

Properties of the regulatory RNA-binding protein HuR and its role in controlling miRNA repression

NC Meisner, W Filipowicz - Regulation of microRNAs, 2010 - Springer
Gene expression in eukaryotes is subject to extensive regulation at posttranscriptional
levels. One of the most important sites of control involves mRNA 3′ untranslated regions …

Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization

CYA Chen, N Xu, AB Shyu - Molecular and cellular biology, 2002 - Taylor & Francis
Human RNA-binding protein HuR, a nucleocytoplasmic shuttling protein, is a ubiquitously
expressed member of the family of Hu proteins, which consist of two N-terminal RNA …

Targeting the multifaceted HuR protein, benefits and caveats

C Zucal, V D'Agostino, R Loffredo, B Mantelli… - Current drug …, 2015 - ingentaconnect.com
The RNA-binding protein (RBP) HuR is one of the most widely studied regulators of the
eukaryotic posttranscriptional gene expression and it plays a physiological role in mediating …