Autophagy, a lysosomal pathway to maintain cellular homeostasis, is mediated via the
mammalian target of rapamycin (mTOR)-dependent pathways. Hepatic stellate cells (HSCs) …

Curcumin, a kind of natural compound, has been previously proven to inhibit the autophagy
in hepatic stellate cells (HSCs) and induce their apoptosis. However, it is not clear whether …

Autophagy and apoptosis are important players in the progression of hepatic fibrosis via
activation of hepatic stellate cells (HSCs). Despite the recently depicted antifibrotic effects of …

Hepatic fibrosis is a key pathological process of chronic liver diseases, caused by alcohol,
toxic and aberrant energy metabolism. It progresses to cirrhosis or even hepatic carcinoma …

The activation of hepatic stellate cells (HSC s) is a prominent event in liver fibrogenesis.
However, how HSC s are activated in the hypoxic microenvironment remains unclear. Here …

Fatty acid-induced lipotoxicity plays a critical role in the pathogenesis of nonalcoholic liver
disease. Saturated fatty acids and unsaturated fatty acids have differential effects on cell …

We investigated the effects of puerarin, the major isoflavone in Kudzu roots, on the
regulation of autophagy in ethanol-treated hepatocytes. Incubation in ethanol (100mM) for …

Macroautophagy, or autophagy, is a cellular response in which unnecessary cytoplasmic
components, including lipids and organelles, are self-degraded. Recent studies closely …

Chronic liver diseases caused by various pathogenesis are marked by inflammatory
infiltration and wound healing reaction, while their normal regeneration ability is impaired …

The activation of hepatic stellate cells (HSCs) is a key event in the development of hepatic
fibrosis caused by arsenic. However, it is unclear how arsenic induces the activation of …