Actin dynamics modulate mechanosensitive immobilization of E-cadherin at adherens junctions

W Engl, B Arasi, LL Yap, JP Thiery, V Viasnoff - Nature cell biology, 2014 - nature.com
Mechanical stress is increasingly being shown to be a potent modulator of cell–cell
junctional morphologies in developmental and homeostatic processes. Intercellular force …

Transmission of cytokinesis forces via E-cadherin dilution and actomyosin flows

D Pinheiro, E Hannezo, S Herszterg, F Bosveld… - Nature, 2017 - nature.com
During epithelial cytokinesis, the remodelling of adhesive cell–cell contacts between the
dividing cell and its neighbours has profound implications for the integrity, arrangement and …

Distinct contributions of tensile and shear stress on E-cadherin levels during morphogenesis

GR Kale, X Yang, JM Philippe, M Mani… - Nature …, 2018 - nature.com
During epithelial morphogenesis, cell contacts (junctions) are constantly remodeled by
mechanical forces that work against adhesive forces. E-cadherin complexes play a pivotal …

E-cadherin junctions as active mechanical integrators in tissue dynamics

T Lecuit, AS Yap - Nature cell biology, 2015 - nature.com
During epithelial morphogenesis, E-cadherin adhesive junctions play an important part in
mechanically coupling the contractile cortices of cells together, thereby distributing the …

Mechanosensitive Adaptation of E-Cadherin Turnover across adherens Junctions

S de Beco, JB Perney, S Coscoy, F Amblard - PloS one, 2015 - journals.plos.org
In the natural and technological world, multi-agent systems strongly depend on how the
interactions are ruled between their individual components, and the proper control of time …

E-cadherin-mediated force transduction signals regulate global cell mechanics

I Muhamed, J Wu, P Sehgal, X Kong… - Journal of cell …, 2016 - journals.biologists.com
This report elucidates an E-cadherin-based force-transduction pathway that triggers
changes in cell mechanics through a mechanism requiring epidermal growth factor receptor …

Active tension: the role of cadherin adhesion and signaling in generating junctional contractility

R Priya, AS Yap - Current topics in developmental biology, 2015 - Elsevier
In this chapter, we discuss the cell biology of contractility at cell–cell junctions. As discussed
elsewhere in this volume, contractile forces play key roles in development and tissue …

Stable force balance between epithelial cells arises from F-actin turnover

JN Jodoin, JS Coravos, S Chanet, CG Vasquez… - Developmental cell, 2015 - cell.com
The propagation of force in epithelial tissues requires that the contractile cytoskeletal
machinery be stably connected between cells through E-cadherin-containing adherens …

Cortical F-actin stabilization generates apical–lateral patterns of junctional contractility that integrate cells into epithelia

SK Wu, GA Gomez, M Michael, S Verma, HL Cox… - Nature cell …, 2014 - nature.com
E-cadherin cell–cell junctions couple the contractile cortices of epithelial cells together,
generating tension within junctions that influences tissue organization. Although junctional …

Neighborly relations: cadherins and mechanotransduction

M Smutny, AS Yap - Journal of Cell Biology, 2010 - rupress.org
Cell–cell adhesions are sites where cells experience and resist tugging forces. It has long
been postulated, but not directly tested, that cadherin adhesion molecules may serve in …