Background: Ethanol addiction has been conceptualized as a progression from occasional,
impulsive use to compulsive behavior. Ethanol‐dependence is a chronic pathology with …

Background: Identification of the brain regions involved in ethanol administration is
important for understanding the neurobiology of ethanol addiction. Animal studies with …

Sensitivity to ethanol intoxication, propensity to drink ethanol and vulnerability to develop
alcoholism are all influenced by genetic factors. Conversely, exposure to ethanol or …

Activation of the mesolimbic dopamine reward pathway by acute ethanol produces
reinforcement and changes in gene expression that appear to be crucial to the molecular …

Chronic ethanol (EtOH) drinking produces neuronal alterations within the limbic system. To
investigate changes in protein expression levels associated with EtOH drinking, inbred …

Background: Homer proteins are constituents of scaffolding complexes that regulate the
trafficking and function of central Group1 metabotropic glutamate receptors (mGluRs) and N …

Neuroadaptations that participate in the ontogeny of alcohol dependence are likely a result
of altered gene expression in various brain regions. The present study investigated brain …

Prolonged exposure of the brain to ethanol is a prerequisite for developing ethanol
dependence, but the underlying neural adaptations are unknown. Here we demonstrate that …

The purpose of this review is to provide an overview of the acute actions of ethanol on signal
transduction, as well as a selective consideration of some of the long-term adaptive changes …

Mice that exhibit characteristics of physical dependence following ethanol exposure serve
as useful models of alcoholism in humans. The DBA/2 J and C57BL/6 J inbred strains differ …