Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep
oscillations and global state control, respectively. Here we silenced a subset of neocortical …

An unknown aspect of behavioral state regulation is how the circadian oscillator of the
suprachiasmatic nucleus (SCN) regulates sleep and waking. In this report, we describe the …

During sleep and awake rest, the neocortex generates large-scale slow-wave (SW) activity.
Here, we report that the claustrum coordinates neocortical SW generation. We established a …

Human sleep is a global state whose functions remain unclear. During much of sleep,
cortical neurons undergo slow oscillations in membrane potential, which appear in …

Sleep is characterized by unique patterns of cortical activity alternating between the stages
of slow-wave sleep (SWS) and rapid-eye movement (REM) sleep. How these patterns relate …

In 2008, Vyazovskiy et al. published a seminal study demonstrating that sleep induces a
widespread downscaling of synapses that counters the synaptic upscaling that occurred …

Sleep and wakefulness are complex, tightly regulated behaviors that occur in virtually all
animals. With recent exciting developments in neuroscience methodologies such as …

Prolonged wakefulness leads to a homeostatic response manifested in increased amplitude
and number of electroencephalogram (EEG) slow waves during recovery sleep. Cortical …

A homeostatic control mechanism that monitors and reacts to the need for sleep has been
thought to function independently of the brain's circadian clock in previous studies. Now …

Sleep is a fundamental biological process observed widely in the animal kingdom, but the
neural circuits generating sleep remain poorly understood. Understanding the brain …