Adipocytokine dysregulation, abnormal glucose metabolism, and lipodystrophy in HIV-infected adolescents receiving protease inhibitors

J Santiprabhob, K Chokephaibulkit, P Khantee… - Cytokine, 2020 - Elsevier
Background Lipodystrophy is common in HIV-infected patients receiving protease inhibitors
(PIs), stavudine, and zidovudine. Adipocytokines may be altered in lipodystrophy. We …

Adipokine profiles and lipodystrophy in HIV‐infected children during the first 4 years on highly active antiretroviral therapy

S Resino, D Micheloud, R Lorente, JM Bellón… - HIV …, 2011 - Wiley Online Library
Objective The aim of the study was to evaluate the evolution of plasma adipokines and
lipodystrophy in protease inhibitor‐naïve vertically HIV‐infected children on highly active …

Lipodystrophy, insulin resistance, and adiponectin concentration in HIV-infected children and adolescents

A Vigano, G Vincenzo Zuccotti, C Cerini… - Current HIV …, 2011 - ingentaconnect.com
Alterations of fat distribution and insulin resistance are associated with increased risk of
metabolic derangements and cardiovascular disease. HIV-infected adult patients on …

Longitudinal evaluation and risk factors of lipodystrophy and associated metabolic changes in HIV-infected children

M Beregszaszi, C Dollfus, M Levine… - JAIDS Journal of …, 2005 - journals.lww.com
Objective: To assess the rate of progression of lipodystrophy and the associated metabolic
disturbances over a 2-year period in children and to assess risk factors associated with …

Altered fat differentiation and adipocytokine expression are inter-related and linked to morphological changes and insulin resistance in HIV-1-infected lipodystrophic …

V Jan, P Cervera, M Maachi, M Baudrimont… - Antiviral …, 2004 - journals.sagepub.com
Objective To achieve a better understand of the pathophysiology of HIV-related lipoatrophy,
we compared the mRNA expression of adipocytokines in fat samples from patients and …

HIV antiretroviral treatment alters adipokine expression and insulin sensitivity of adipose tissue in vitro and in vivo

C Lagathu, M Kim, M Maachi, C Vigouroux, P Cervera… - Biochimie, 2005 - Elsevier
HIV-1-infected patients on antiretroviral therapy frequently develop a lipodystrophy
syndrome, characterized by peripheral lipoatrophy and visceral fat redistribution associated …

Association between lipodystrophy and leptin in human immunodeficiency virus-1-infected children receiving lopinavir/ritonavir-based therapy

S Resino, C Palladino, R Lorente… - The Pediatric …, 2010 - journals.lww.com
Highly active antiretroviral therapy might lead to the development of dyslipidemia and
lipodystrophy (LD) syndrome. We carried out a multicenter prospective study of 22 human …

Adipose tissue inflammation and altered adipokine and cytokine production in antiretroviral therapy-associated lipodystrophy

E Hammond, D Nolan - Current Opinion in HIV and AIDS, 2007 - journals.lww.com
Lipodystrophy can be avoided by selecting therapies with benign effects on adipose tissue.
Switching from certain HIV protease inhibitors may normalize the metabolic profile fairly …

Altered adipokine response in murine 3T3-F442A adipocytes treated with protease inhibitors and nucleoside reverse transcriptase inhibitors

SP Jones, O Janneh, DJ Back… - Antiviral …, 2005 - journals.sagepub.com
Background Abnormal levels of tumour necrosis factor (TNF)-α, interleukin (IL)-6 and
adiponectin have been observed in HIV patients with lipodystrophy. However, because …

Monitoring of lipodystrophic and metabolic abnormalities in HIV-1 infected children on antiretroviral therapy

V Spoulou, C Kanaka-Gantenbein, I Bathrellou, S Mora… - Hormones, 2011 - Springer
OBJECTIVE: Few studies have thus far assessed body composition by dual energy X-ray
absorptrometry (DXA) in children with HIV, primarily because reference data for normally …