The habenula in psychiatric disorders: more than three decades of translational investigation

M Fakhoury - Neuroscience & Biobehavioral Reviews, 2017 - Elsevier
The habenula is an epithalamic structure located at the center of the dorsal diencephalic
conduction system, a pathway involved in linking forebrain to midbrain regions. Composed …

Translating the habenula—from rodents to humans

LJ Boulos, E Darcq, BL Kieffer - Biological psychiatry, 2017 - Elsevier
The habenula (Hb) is a central structure connecting forebrain to midbrain regions. This
microstructure regulates monoaminergic systems, notably dopamine and serotonin, and …

[HTML][HTML] Understanding the habenula: A major node in circuits regulating emotion and motivation

JL Ables, K Park, I Ibañez–Tallon - Pharmacological research, 2023 - Elsevier
Over the last decade, the understanding of the habenula has rapidly advanced from being
an understudied brain area with the Latin name 'habena” meaning “little rein”, to being …

[HTML][HTML] The role of the medial habenula cholinergic system in addiction and emotion-associated behaviors

HW Lee, SH Yang, JY Kim, H Kim - Frontiers in psychiatry, 2019 - frontiersin.org
The habenula is a complex nucleus composed of lateral and medial subnuclei, which
connect between the limbic forebrain and midbrain. Over the past few years, the lateral …

Circuits and functions of the lateral habenula in health and in disease

H Hu, Y Cui, Y Yang - Nature Reviews Neuroscience, 2020 - nature.com
The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …

Habenula: crossroad between the basal ganglia and the limbic system

O Hikosaka, SR Sesack, L Lecourtier… - Journal of …, 2008 - Soc Neuroscience
There is a growing awareness that emotion, motivation, and reward values are important
determinants of our behavior. The habenula is uniquely positioned both anatomically and …

The lateral habenula in addiction and depression: an anatomical, synaptic and behavioral overview

S Lecca, FJ Meye, M Mameli - European Journal of …, 2014 - Wiley Online Library
The lateral habenula (LH b) is an epithalamic region with a crucial role in the regulation of
midbrain monoaminergic systems. Over the past few years a renewed interest in the LH b …

Toward an understanding of the habenula's various roles in human depression

H Aizawa, M Zhu - Psychiatry and clinical neurosciences, 2019 - Wiley Online Library
The habenula is an evolutionarily conserved structure in the vertebrate brain. Lesion and
electrophysiological studies in animals have suggested that it is involved in the regulation of …

[HTML][HTML] The role of the habenula in drug addiction

KM Velasquez, DL Molfese, R Salas - Frontiers in human …, 2014 - frontiersin.org
Interest in the habenula has greatly increased in recent years. The habenula is a small brain
structure located posterior to the thalamus and adjacent to the third ventricle. Despite its …

Habenular connections with the dopaminergic and serotonergic system and their role in stress‐related psychiatric disorders

M Metzger, R Souza, LB Lima, D Bueno… - European Journal of …, 2021 - Wiley Online Library
The habenula (Hb) is a phylogenetically old epithalamic structure differentiated into two
nuclear complexes, the medial (MHb) and lateral habenula (LHb). After decades of search …