Rationale Chronic stress results in cognitive impairment, affects hippocampal neurogenesis
and is known to precipitate affective disorders such as depression. In addition to stress …

Chronic stress in rats has been shown to impair learning and memory, and precipitate
several affective disorders like depression and anxiety. The mechanisms involved in these …

Rationale In depressive disorders, one of the mechanisms proposed for antidepressant
drugs is the enhancement of synaptic plasticity in the hippocampus and cerebral cortex …

Cancer patients often suffer long-lasting affective and cognitive impairments as a result of
chemotherapy treatment. Previous work in our lab has shown deficits in learning and …

The primary objective of our study is to investigate the neuroprotective efficacy of honokiol
and imipramine against restraint stress (RS)-induced cognitive impairment and depressive …

Major depression is hypothesized to be associated with dysregulations of the hypothalamic–
pituitary–adrenal (HPA) axis and impairments in adult hippocampal neurogenesis. Adult …

Background Rhodomyrtone is one of the main active compounds derived from Rhodomyrtus
tomentosa, which belongs to the Myrtaceae family. In the current study, we investigated the …

Adult hippocampal neurogenesis has been demonstrated in several species and is
regulated by both environmental and pharmacological stimuli. Repeated exposure to stress …

Rationale Previous studies have demonstrated that piromelatine (a melatonin and serotonin
5-HT1A and 5-HT1D agonist) exerts an antidepressant activity in rodent models of acute …

Stress and antidepressants have been shown to influence hippocampal neurogenesis,
which is hypothesized to be an etiological factor of depression. Robust ischemia-stimulated …