Simple Summary Several plant-based compounds inhibit tumor cell growth. Selective
modification of these compounds significantly increases their antitumor potency. The goal of …

Chemoprevention impels the pursuit for either single targeted or cocktail of multi-targeted
agents. Bromelain, potential agent in this regard, is a pharmacologically active compound …

Mitochondrion is a favorable therapeutic target in cancer, given its regulation of
bioenergetics and cell death. Honokiol exhibits antiproliferative effects through mitochondria …

The medicinal qualities of pineapple are recognized in many traditions in South America,
China and Southeast Asia. These qualities are attributed to bromelain, a 95%-mixture of …

Mitochondria are the respiratory and energetic centers of the cell where multiple intra-and
extracellular signal transduction pathways converge leading to dysfunction of those …

Plant-derived bioactive compounds displayed major therapeutic and chemo-preventive
roles in the pathogenesis of numerous chronic malignancies such as cancer and enhanced …

The use of nutraceuticals during cancer treatment is a long‐lasting debate. Berberine (BBR)
is an isoquinoline quaternary alkaloid extracted from a variety of medicinal plants. BBR has …

The natural anti-cancer agent bromelain is found to be beneficial for either single or multi-
targeted therapy in gastric and skin carcinoma, by inhibiting cancer cell growth. Importantly …

Major obstacles in current breast cancer treatment efficacy include the ability of breast
cancer cells to develop resistance to chemotherapeutic drugs and the off-target cytotoxicity …

Glioblastoma (GB) is the most common and aggressive primary malignant astrocytoma
correlated with poor patient survival. There are no curative treatments for GB, and it …