Phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P 2] is a multi-functional lipid that regulates
several essential subcellular processes in eukaryotic cells. In addition to its well-established …

Phosphatidylinositol 4, 5-bisphosphate (PI (4, 5) P2) is a minor but ubiquitous component of
the inner leaflet of the plasma membrane of eukaryotic cells. However, due to its particular …

In the almost 70 years since the first hints of its existence, the phosphoinositide,
phosphatidyl-D-myo-inositol 4, 5-bisphosphate has been found to be central in the …

Phosphoinositides are an important class of anionic, low abundance signaling lipids
distributed throughout intracellular membranes. The plasma membrane contains three …

Abstract Phosphatidylinositol 4, 5-bisphosphate [PI (4, 5) P 2] is a minor lipid of the inner
leaflet of the plasma membrane that controls the activity of numerous proteins and serves as …

Phosphoinositides are minor constituents of eukaryotic membranes but participate in a wide
range of cellular processes. The most abundant and best characterized phosphoinositide …

Located at the inner leaflet of the plasma membrane (PM), phosphatidyl-inositol 4, 5-
bisphosphate [PI (4, 5) P2] composes only 1–2 mol% of total PM lipids. With its synthesis …

The phosphatidylinositol phosphate (PIP) kinases are a unique family of enzymes that
generate an assortment of lipid messengers, including the pivotal second messenger …

Phosphatidylinositol lipids are signaling molecules involved in nearly all aspects of cellular
regulation. Production of phosphatidylinositol 4-phosphate (PI4P) has long been recognized …

Abstract Phosphatidylinositol 4, 5‐bisphosphate (PI4, 5P2) is a key lipid signaling molecule
that regulates a vast array of biological activities. PI4, 5P2 can act directly as a messenger or …