The cellular basis of tumor progression
GH Heppner, FR Miller - International review of cytology, 1997 - Elsevier
Variability in disease presentation and course is a hallmark of cancer. Variability is seen
among similarly diagnosed cancers in different patients or animal hosts and in the same …
among similarly diagnosed cancers in different patients or animal hosts and in the same …
Cellular heterogeneity and molecular evolution in cancer
V Almendro, A Marusyk, K Polyak - Annual Review of Pathology …, 2013 - annualreviews.org
Intratumor heterogeneity represents a major obstacle to effective cancer treatment and
personalized medicine. However, investigators are now elucidating intratumor heterogeneity …
personalized medicine. However, investigators are now elucidating intratumor heterogeneity …
[HTML][HTML] A narrative review of tumor heterogeneity and challenges to tumor drug therapy
L Zhu, M Jiang, H Wang, H Sun, J Zhu… - Annals of …, 2021 - ncbi.nlm.nih.gov
Objective To accurately evaluate tumor heterogeneity, make multidimensional diagnosis
according to the causes and phenotypes of tumor heterogeneity, and assist in the …
according to the causes and phenotypes of tumor heterogeneity, and assist in the …
[HTML][HTML] Tumor heterogeneity: biological implications and therapeutic consequences
GH Heppner, BE Miller - Cancer and Metastasis Reviews, 1983 - Springer
It is now appreciated that cancers can be composed of multiple clonal subpopulations of
cancer cells which differ among themselves in many properties, including karyotype, growth …
cancer cells which differ among themselves in many properties, including karyotype, growth …
Genetic and epigenetic heterogeneity in cancer: a genome‐centric perspective
HHQ Heng, SW Bremer, JB Stevens… - Journal of cellular …, 2009 - Wiley Online Library
Genetic and epigenetic heterogeneity (the main form of non‐genetic heterogeneity) are key
elements in cancer progression and drug resistance, as they provide needed population …
elements in cancer progression and drug resistance, as they provide needed population …
Heterogeneity and cancer
KH Allison, GW Sledge - Oncology, 2014 - go.gale.com
Cancer heterogeneity, long recognized as an important clinical determinant of patient
outcomes, was poorly understood at a molecular level. Genomic studies have significantly …
outcomes, was poorly understood at a molecular level. Genomic studies have significantly …
[HTML][HTML] Natural and chemotherapy-induced clonal evolution of tumors
MK Ibragimova, MM Tsyganov, NV Litviakov - Biochemistry (Moscow), 2017 - Springer
Evolution and natural selection of tumoral clones in the process of transformation and the
following carcinogenesis can be called natural clonal evolution. Its main driving factors are …
following carcinogenesis can be called natural clonal evolution. Its main driving factors are …
[引用][C] Cytogenetics of tumor progression
PC Nowell - Cancer, 1990 - Wiley Online Library
T quire more aggressive characteristics and more malignant behavior has long been
recognized, and termed “tumor progression.” Foulds' pointed out that this phenomenon often …
recognized, and termed “tumor progression.” Foulds' pointed out that this phenomenon often …
[HTML][HTML] Dynamic cancer cell heterogeneity: Diagnostic and therapeutic implications
V Jacquemin, M Antoine, G Dom, V Detours… - Cancers, 2022 - mdpi.com
Simple Summary Cancer heterogeneity, which occurs in most cancer patients, has been
known and studied by experienced pathologists since the early 19th century. Intratumoral …
known and studied by experienced pathologists since the early 19th century. Intratumoral …
Genetic and epigenetic heterogeneity in cancer: the ultimate challenge for drug therapy
HH Heng, G Liu, JB Stevens, SW Bremer… - Current drug …, 2010 - ingentaconnect.com
Based on the gene and pathway centric concept of cancer, current approaches to cancer
drug treatment have been focused on key molecular targets specific and essential for cancer …
drug treatment have been focused on key molecular targets specific and essential for cancer …