Analogous to life on earth, tumor cells evolve through space and time and adapt to different
micro-environmental conditions. As a result, tumors are composed of millions of genetically …

Intratumor heterogeneity has been widely reported in human cancers, but our knowledge of
how this genetic diversity emerges over time remains limited. A central challenge in studying …

Alterations in the expression of certain genes or in their products can render benign tumor
cells metastatic. Experimentally this has been quickly performed by transferring dominantly …

The population of cells that make up a cancer are manifestly heterogeneous at the genetic,
epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra …

Cancer patients die primarily due to disease recurrence after transient treatment responses.
The emergence of therapy‐resistant escape variants is fuelled by intra‐tumour …

Most tumours, even those of the same histological type and grade, demonstrate
considerable biological heterogeneity. Variations in genomic subtype, growth factor …

Abstract Using Affymetrix HG-U133 Plus 2.0 array and laser capture microdissection
techniques, we determined whether different zones of the same pancreatic tumor exhibited …

Recent technologic advances have permitted higher resolution and more rapid analysis of
individual cancer genomes at the single-nucleotide level. Such advances have shown …

This paper discusses selected activities, issues, and challenges in recent development of
analytical methods and applications in biomarker identification and validation using state-of …

Cancer development is driven by the accumulation of DNA changes in the approximately 40
000 chromosomal genes. In solid tumours, chromosomal numerical/structural aberrations …