Dietary restriction, or reduced food intake without malnutrition, increases life span, health
span, and acute stress resistance in model organisms from yeast to nonhuman primates …

Protein restriction (PR) is important for the benefits of dietary restriction on longevity and
stress resistance, but relevant nutrient sensors and downstream effectors in mammals …

Dietary restriction (DR) extends lifespan and increases resistance to multiple forms of stress,
including ischemia reperfusion injury to the brain and heart in rodents. While maximal effects …

Appropriate regulation of the Integrated stress response (ISR) and mTORC1 signaling are
central for cell adaptation to starvation for amino acids. Halofuginone (HF) is a potent …

Background and Purpose—Ischemia elicits the rapid release of various amino acid
neurotransmitters. A glutamate surge activates N-methyl-d-aspartate (NMDA) glutamate …

Background: Short-term dietary restriction (DR) without malnutrition preconditions against
surgical stress in rodents; however, the nutritional basis and underlying nutrient/energy …

We previously demonstrated that glucose and glutamine, solutes metabolized by the gut,
replenish ATP and enhance gut function compared with alanine, a solute not metabolized by …

Food restriction improves metabolic health and increases resistance to stress in
experimental animals. However, most studies have focused on long-term dietary restriction …

The tumor microenvironment is characterized by deficiencies in oxygen and nutrients, such
as glucose and amino acids. Activation of the GCN2 arm of the Integrated Stress Response …

INTRODUCTION: The amino acid glutamine (GLN) has received considerable attention as a
potential therapeutic adjuvant in critical illness and in improving postoperative clinical …