Interleukin‐10 (IL‐10) is an anti‐inflammatory cytokine. Its production in humans is under
genetic control, and genotype defines high or low producers of this cytokine. This study …

Although genetic predisposition for inflammatory bowel disease (IBD) is well established,
little is known about the accountable genes. The pathogenesis of IBD is characterized by an …

Abstract Interleukin-10 (IL-10) has a key role in regulating mucosal inflammation. The role of
functional polymorphisms at positions− 627 and− 1117 in the IL-10 gene as candidate …

Interleukin‐18 (IL‐18) is believed to be one of the most important cytokines in the
pathogenesis of inflammatory bowel disease (IBD). The aim of the study was to clarify the …

Recently, a T-to-C polymorphism at position− 295 in the promoter region of the human
interleukin-16 (IL-16) gene was reported. The expression of IL-16 is increased in …

Objective. Pathological evidence supports a potential role of the pro-and anti-inflammatory
cytokine network in the pathogenesis of inflammatory bowel disease (IBD). Moreover …

Although the importance of genetic susceptibility to IBD has been established by
epidemiological studies, the genes involved remain poorly characterized. Important …

Interleukin 6 (IL6) is an inflammatory cytokine; signaling via its receptor (IL6R) is believed to
contribute to development of inflammatory bowel diseases (IBD). The single nucleotide …

Background. The etiology of inflammatory bowel disease, which includes ulcerative colitis
and Crohn's disease, has not yet been made clear. However, inflammatory bowel disease is …

Imbalances in the regulation of Th1 and Th2 lymphocytes are crucial in inflammatory bowel
diseases. Interleukin-4 is secreted by Th2 lymphocytes and downregulates cytokine …