N6-Cyclohexyl [3H] adenosine ([3H] CHA) and 1, 3-diethyl-8-[3H] phenylxanthine ([3H] DPX)
to bind to adenosine receptors in brain membranes. The agonist [3H] CHA has high affinity …

Guamne nucleotides, divalent cations, and sodium differentially regulate agonist and
antagonist binding to adenosine A, receptors in brain membranes. Guanine nucleotides …

The presence of distinct binding sites for adenosine in both the CNS and PNS has been
proposed in numerous studies. The recent availability of stable adenosine analogues such …

A series of 28 adenosine analogs and 17 xanthines has been assessed as inhibitors of
binding of N 6‐R‐[3H]‐phenylisopropyladenosine binding to A1 adenosine receptors in …

Cyclopentyl-1, 3-dipropylxanthine (PD 116,948) is a very potent, very A 1-selective
adenosine antagonist, with a K i of 0.46 nM in 3 H-CHA binding to A 1 receptors in rat whole …

An amine-functionalized derivative of 1, 3-dipropyl-8-phenylxanthine has been prepared in
tritiated form as a xanthine amine congener ([3H] XAC) for use as an antagonist radioligand …

A possible heterogeneity of adenosine A 1 receptors in brain was evaluated by comparing
drug specificity, regional distribution, and temperature influences on 3 H-labeled ligand …

Adenosine has a significant role in many functions of the central nervous system.
Behaviorally, adenosine and adenosine analogs have marked depressant effects …

Numerous investigations indicate a role for adenosine in neurotransmission or
neuromodulation actions which appear to be mediated in brain by at least two types of …

The potencies of caffeine and related methylxanthines as adenosine antagonists were
assessed with respect to three apparent subtypes of adenosine receptors in rat brain …