In females, estrogens play a key role in reproduction and have beneficial effects on the
skeletal, cardiovascular, and central nervous systems. Most estrogenic responses are …

Synthetic estrogen receptor ligands such as tamoxifen and raloxifene produce biologic
responses which can be either estrogenic or anti-estrogenic, depending upon the tissue in …

Despite the beneficial effects of estrogens in women's health, there is a plethora of evidence
that suggest an important role for these hormones, particularly 17β-estradiol (E2), in the …

By regulating activities and expression levels of key signaling molecules, estrogens control
mechanisms that are responsible for crucial cellular functions. Ligand binding to estrogen …

Estrogens exert profound effects on the physiology of diverse target cells and these effects
appear to be mediated by two estrogen receptor (ER) subtypes, ERα and ERβ. We have …

Estrogens and selective estrogen receptor modulators (SERMs) interact with estrogen
receptor (ER) α and β to activate or repress gene transcription. To understand how …

Estrogens and selective estrogen receptor modulators (SERMs) interact with estrogen
receptor (ER) α and β to activate or repress gene transcription. To understand how …

Estrogens display intriguing tissue-selective action that is of great biomedical importance in
the development of optimal therapeutics for the prevention and treatment of breast cancer …

Estrogenic effects are mediated through two estrogen receptor (ER) subtypes, ERα and
ERβ. Estrogens are the most commonly prescribed drugs to treat menopausal conditions …

The action of nuclear hormone receptors is tripartite, involving the receptor, its ligands, and
its co-regulator proteins. The estrogen receptor (ER), a member of this superfamily, is a …