Despite global vaccination programs, infections with severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) continue to cause severe disease with significant morbidity …

Elevated levels of cytokines IL-1β and IL-6 are associated with severe COVID-19.
Investigating the underlying mechanisms, we find that while primary human airway epithelia …

Immunothrombosis—immune-mediated activation of coagulation—is protective against
pathogens, but excessive immunothrombosis can result in pathological thrombosis and …

The COVID-19 pandemic was caused by the recently emerged β-coronavirus SARS-CoV-2.
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …

Background Coronavirus-associated acute respiratory distress syndrome (CARDS) has
limited effective therapy to date. NLRP3 inflammasome activation induced by SARS-CoV-2 …

Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory syndrome coronavirus (SARS-CoV)-2, continues to cause substantial morbidity …

Most COVID-19 infected individuals present with mild flu-like symptoms; however, 5–10% of
cases suffer from life-threatening pneumonia and respiratory failure. The pathogenesis of …

Coronaviruses (CoVs) are members of the genus Betacoronavirus and the Coronaviridiae
family responsible for infections such as severe acute respiratory syndrome (SARS), Middle …

A recent mutation analysis suggested that Non-Structural Protein 6 (NSP6) of the Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant of the viral …

Objective The orf8b protein of the coronavirus SARS-CoV, analogous to SARS-CoV-2,
triggers the NLRP3 inflammasome in macrophages in vitro. Deregulated inflammasome …