Overly exuberant innate immune response to SARS-CoV-2 infection
Z Zhou, L Ren, LI Zhang, J Zhong, Y Xiao, Z Jia, L Guo… - 2020 - papers.ssrn.com
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2
infection has posed a severe threat to global public health. It is unclear how the human …
infection has posed a severe threat to global public health. It is unclear how the human …
Inflammatory pathways in COVID‐19: mechanism and therapeutic interventions
Y Jiang, T Zhao, X Zhou, Y Xiang… - MedComm, 2022 - Wiley Online Library
Abstract The 2019 coronavirus disease (COVID‐19) pandemic has become a global crisis.
In the immunopathogenesis of COVID‐19, SARS‐CoV‐2 infection induces an excessive …
In the immunopathogenesis of COVID‐19, SARS‐CoV‐2 infection induces an excessive …
Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2
To date, no vaccines or effective drugs have been approved to prevent or treat COVID-19
and the current standard care relies on supportive treatments. Therefore, based on the fast …
and the current standard care relies on supportive treatments. Therefore, based on the fast …
Heightened innate immune responses in the respiratory tract of COVID-19 patients
The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2
infection have posed a severe threat to global public health. It is unclear how the human …
infection have posed a severe threat to global public health. It is unclear how the human …
Innate immunological pathways in COVID-19 pathogenesis
SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …
dysregulation of the innate immune system. This knowledge has emerged from the large …
COVID-19 as an acute inflammatory disease
RH Manjili, M Zarei, M Habibi… - The journal of immunology, 2020 - journals.aai.org
Abstract The 2019 coronavirus disease (COVID-19) pandemic caused by the virus severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has created an unprecedented …
acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has created an unprecedented …
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …
Role of IFN and complements system: innate immunity in SARS-CoV-2
T Shibabaw, MD Molla, B Teferi… - Journal of inflammation …, 2020 - Taylor & Francis
The critical role of the innate immune system has been confirmed in driving local and
systemic inflammation and the cytokine release storm in severe acute respiratory syndrome …
systemic inflammation and the cytokine release storm in severe acute respiratory syndrome …
In COVID-19, NLRP3 inflammasome genetic variants are associated with critical disease and these effects are partly mediated by the sickness symptom complex: a …
M Maes, WLD Tedesco Junior, MAB Lozovoy… - Molecular …, 2022 - nature.com
Abstract In coronavirus disease (COVID-19), the nucleotide-binding domain, leucine-rich
repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome is activated in …
repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome is activated in …
Dysregulated innate and adaptive immune responses discriminate disease severity in COVID-19
NAF Janssen, I Grondman… - The Journal of …, 2021 - academic.oup.com
The clinical spectrum of COVID-19 varies and the differences in host response
characterizing this variation have not been fully elucidated. COVID-19 disease severity …
characterizing this variation have not been fully elucidated. COVID-19 disease severity …