DNA methylation is one of epigenetic mechanisms regulating gene expression. The
methylation pattern is determined during embryogenesis and passed over to differentiating …

DNA methylation is one of the epigenetic modifications of the genome, the essence of which
is the attachment of a methyl group to nitrogenous bases. In the eukaryote genome, cytosine …

Carcinoma of the lung is the most common cause of cancer death worldwide. The estimated
5-year survival ranges from 6–16%, depending on the cell type. The best opportunity for …

Non-CpG methylation of cytosine residues, a mechanism associated with regulation of gene
expression, has not been investigated in human cancer until now. Analysis of the p53 exon …

It has become apparent that the genomes of many organisms are characterized by unique
patterns of DNA methylation which can differ from genome segment to genome segment and …

Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …

The methylation of DNA is an epigenetic modification that can play an important role in the
control of gene expression in mammalian cells. The enzyme involved in this process is DNA …

DNA methylation is one of the most intensely studied epigenetic modifications in mammals.
In normal cells, it assures the proper regulation of gene expression and stable gene …

The main thrusts of the arguments that aberrant DNA methylation is involved in the
generation of tumor heterogeneity and progression can be summarized as follows. The …

Genetic and epigenetic aspects of DNA methylation on genome expression, evolution, mutation
and carcinogenesis Page 1 Carcinogenesis vol.18 no.5 pp.869–882, 1997 COMMENTARY …