DNA methylation plays an important role in the establishment and maintenance of the
program of gene expression. Tumor cells are characterized by a paradoxical alteration of …

Summary Eukaryotic genomes contain 5-methylcytosine (5mC) as a rare base. 5mC arises
by postsynthetic modification of cytosine and occurs, at least in animals, predominantly in …

Integrated analysis of DNA methylation and gene expression can reveal specific epigenetic
patterns that are important during carcinogenesis. We built an integrated database of DNA …

DNA methylation is an important epigenetic mechanism in mammalian cells. It occurs almost
exclusively at CpG sites and has a key role in a number of biological processes. It plays an …

Methylation of CpG dinucleotides is an epigenetic mechanism involved in the regulation of
gene expression in mammals. The patterns of CpG methylation are specie and tissue …

DNA methylation is the main epigenetic modification in humans, and changes in methylation
patterns play an important role in tumorigenesis. Hypermethylation of normally unmethylated …

DNA hypermethylation is believed to be involved in human carcinogenesis, since it
suppresses the transcription of defined genes and is associated with chromosomal …

Alterations in global DNA methylation have been observed in many cancers, but whether
such alterations represent an epigenetic difference in susceptibility for the disease is …

Methylation of cytosines at their carbon-5 position plays an important role both during
development and in tumorgenesis. The methylation occurs almost exclusively in CpG …

There is strong evidence that DNA methylation is not a neutral bystander in carcinogenesis,
but actively contributes to the process. Methylation of cytosine is known to promote mutation …