The study of the biological role of DNA methylation in vertebrates has involved considerable
controversy. Research in this area has proceeded well despite the complexity of the subject …

Cancer cell lines are widely used in many types of cancer research, including studies aimed
at understanding DNA hypermethylation of gene promoters in cancer. Hypermethylation of …

The DNA of many organisms contains modified bases such as 5-methylcytosine and 6-
methyladenine, in addition to the four unmodified bases (reviewed by Razin and Szyf …

Publisher Summary The chapter discusses on the DNA methylation and its possible
biological roles. The pattern of DNA methylation is species-specific. In the DNA of some …

Alterations of DNA methylation are one of the most consistent epigenetic changes in human
cancers. Human cancers generally show global DNA hypomethylation accompanied by …

Aberrant DNA methylation is a frequent phenomenon in non-small cell lung cancers. We
have used a microarray approach to assess the methylation status of 245 CpG positions in …

Publisher Summary This chapter discusses the role of DNA methylation in carcinogenesis
and tumor diversification. The methylation of HpaII and Hha1 sites in DNA isolated from the …

An immunodetection technique has been developed to map with high resolution the
methylated sites of human chromosomes. We have used this method to define the …

Early detection appears to be one of the most important approaches to reducing mortality
caused by neoplasia. Changes in DNA methylation have been recognized as one of the …

DNA methylation is the main epigenetic modification in humans. The methylation of
promoter inhibits the transcription in most genes. In normal tissues, isolated CpG …