Many processes in female reproductive physiology depend on progesterone. This hormone
facilitates the action of estradiol in inducing the luteinizing hormone (LH) surge in the …

Mifepristone is a progesterone antagonist that has been studied for a number of clinical
applications. It is a well-known abortifacient that is effective for both first-and second …

The first clinically available antiprogestin, mifepristone has generated immense interest in
the research community since its' discovery in 1980. Mifepristone is a synthetic orally active …

Roussel Uclaf in partnership with the INSERM unit of Prof. EE Baulieu first discovered
mifepristone (RU486) as part of a large research program on steroidal compounds with …

Mifepristone is a progesterone and glucocorticoid receptor antagonist. Medical abortion with
mifepristone and prostaglandin has revolutionized the abortion process extending abortion …

Importance of the field: Mifepristone is a synthetic selective progesterone-receptor modulator
(SPRM) that is widely used around the globe in the field of reproductive medicine. At present …

Nowadays, unwanted pregnancy is a major globe tragedy for millions of women, associated
with significant direct and indirect costs, no matter for individuals or society. The …

Synopsis Mifepristone is a potent oral antiprogestogen which acts at the level of the
receptor, having a high affinity for the progesterone receptor. Most of the clinical trials have …

The discovery of mifepristone (ex-RU486) was the achievement of a large research
programme on steroidal compounds with antihormone properties conducted at Roussel …

Since the discovery of the progesterone receptor antagonist mifepristone, numerous
additional compounds, which display a spectrum of biological actions ranging from full …