Highly immunostimulatory CpG-free oligodeoxynucleotides for activation of human leukocytes
J Vollmer, A Janosch, M Laucht, ZK Ballas… - … and Nucleic Acid …, 2002 - liebertpub.com
Synthetic oligodeoxynucleotides (ODNs) bearing CpG dinucleotides can mimic the
immunostimulatory effects of bacterial DNA in vertebrates. Besides the known CpG motifs …
immunostimulatory effects of bacterial DNA in vertebrates. Besides the known CpG motifs …
Immunostimulatory PyNTTTTGT oligodeoxynucleotides: structural properties and refinement of the active motif
JM Rodriguez, F Elías, J Fló, RA López… - …, 2006 - liebertpub.com
It is well known that synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG
dinucleotides within a given context stimulate B lymphocytes and plasmacytoid dendritic …
dinucleotides within a given context stimulate B lymphocytes and plasmacytoid dendritic …
Heterogeneity in the human response to immunostimulatory CpG oligodeoxynucleotides
CA Leifer, D Verthelyi, DM Klinman - Journal of Immunotherapy, 2003 - journals.lww.com
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs trigger an
immune response characterized by proliferation, B-cell activation, and cytokine production …
immune response characterized by proliferation, B-cell activation, and cytokine production …
Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine …
ER Kandimalla, L Bhagat, D Wang, D Yu… - Nucleic Acids …, 2003 - academic.oup.com
Unmethylated CpG dinucleotides present within certain specific sequence contexts in
bacterial and synthetic DNA stimulate innate immune responses and induce cytokine …
bacterial and synthetic DNA stimulate innate immune responses and induce cytokine …
Effects of a hexameric deoxyriboguanosine run conjugation into CpG oligodeoxynucleotides on their immunostimulatory potentials
CpG oligodeoxynucleotides (ODNs) are promising immunomodulatory agents for treating
human diseases and vaccine development. Phosphodiester CpG ODNs were demonstrated …
human diseases and vaccine development. Phosphodiester CpG ODNs were demonstrated …
Immunostimulatory activity of CpG oligonucleotides containing non-ionic methylphosphonate linkages
D Yu, ER Kandimalla, Q Zhao, Y Cong… - Bioorganic & medicinal …, 2001 - Elsevier
Bacterial DNA and synthetic oligodeoxynucleotides containing unmethylated CpG-motifs in
a particular sequence context activate vertebrate immune cells. We examined the …
a particular sequence context activate vertebrate immune cells. We examined the …
Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides
Synthetic oligodeoxynucleotides (ODN) containing CpG sequences are recognized as a
“danger” signal by the immune system of mammals. As a consequence, CpG ODN stimulate …
“danger” signal by the immune system of mammals. As a consequence, CpG ODN stimulate …
Use of CpG oligodeoxynucleotides as immune adjuvants
DM Klinman, D Currie, I Gursel… - Immunological …, 2004 - Wiley Online Library
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the …
Mechanisms and applications of immune stimulatory CpG oligodeoxynucleotides
AM Krieg - Biochimica et Biophysica Acta (BBA)-Gene Structure …, 1999 - Elsevier
Immune stimulation has been widely recognized as an undesirable side effect of certain
antisense oligodeoxynucleotides (ODN) which can interfere with their therapeutic …
antisense oligodeoxynucleotides (ODN) which can interfere with their therapeutic …
Immunostimulatory activity of CpG oligonucleotides containing non-ionic methylphosophonate linkages
D Yu, E Kandimalla, Q Zhao… - US Patent App. 10/137,687, 2003 - Google Patents
Bacterial DNA and synthetic oligodeoxynucleotides containing unmethylated CpG-motifs in
a particular sequence context activate vertebrate immune cells. We examined the …
a particular sequence context activate vertebrate immune cells. We examined the …