Background and Objectives: PNU-74654, a Wnt/β-catenin inhibitor, has reported antitumor
activities; however, the therapeutic potential of PNU-74654 in hepatocellular carcinoma …

Background and Objectives: PNU-74654, a Wnt/β-catenin pathway inhibitor, has an
antiproliferative effect on many cancer types; however, its therapeutic role in pancreatic …

Background Colorectal-cancer (CRC) is amongst the most lethal-cancers, mainly due to its
metastatic spread and drug chemoresistance. Hence there is a need for new approaches to …

FH535 is a small-molecule inhibitor of the Wnt/β-catenin signaling pathway, which a
substantial body of evidence has proven is activated in various cancers, including …

Hepatocellular carcinoma (HCC) is a primary cancer of the liver. Target therapy may
improve prognosis of HCC. In the present study, we evaluated the inhibition of the Wnt/β …

Purpose: Colorectal cancer (CRC) is one of the most frequent tumors and causes of mortality
worldwide. Ubiquitin ligase was reported to regulate multiple cellular processes, including …

Background/Aim: To explore the possibility of a selective small-molecule β-catenin inhibitor,
CWP232228, as a potential therapeutic drug in the treatment of colorectal cancer (CRC) …

Aberrant Wnt/β-catenin pathway activation is frequently observed in human colorectal
cancer (CRC) and has become a promising target for CRC treatment. Our study aimed to …

Background The hyperactivation of β-catenin signaling is frequently observed in clinical
hepatocellular carcinoma (HCC) samples. Further understanding the mechanisms involved …

Background Hepatocellular carcinoma (HCC) is the second lethal malignancy among all
cancers. Many molecular alterations have been found in HCC. However, the interactions …