A review of neuroprotection pharmacology and therapies in patients with acute traumatic brain injury

KW McConeghy, J Hatton, L Hughes, AM Cook - CNS drugs, 2012 - Springer
Traumatic brain injury (TBI) affects 1.6 million Americans annually. The injury severity
impacts the overall outcome and likelihood for survival. Current treatment of acute TBI …

Neuroprotection trials in traumatic brain injury

S Chakraborty, B Skolnick, RK Narayan - Current neurology and …, 2016 - Springer
Traumatic brain injury (TBI) is a significant cause of mortality and morbidity worldwide.
Current treatment of acute TBI includes surgical intervention when needed, followed by …

Targets of neuroprotection and review of pharmacological interventions in traumatic brain injury

MI Hiskens - Journal of Pharmacology and Experimental …, 2022 - ASPET
Traumatic brain injury (TBI) is a major contributor to disability and death worldwide, and
manifests in cognitive, behavioral, and motor impairment. Although there have been …

Neuroprotection in traumatic brain injury: a complex struggle against the biology of nature

JW Schouten - Current opinion in critical care, 2007 - journals.lww.com
Traumatic brain injury is a complex disease, and development of clinically effective
neuroprotective agents is a difficult task. Experimental traumatic brain injury has provided …

Emerging treatments for traumatic brain injury

Y Xiong, A Mahmood, M Chopp - Expert opinion on emerging drugs, 2009 - Taylor & Francis
Background: This review summarizes promising approaches for the treatment of traumatic
brain injury (TBI) that are in either preclinical or clinical trials. Objective: The …

Medical treatment and neuroprotection in traumatic brain injury

T Clausen, R Bullock - Current pharmaceutical design, 2001 - ingentaconnect.com
The goal of this article is to give an overview about the established current treatment
concepts of traumatic brain injury, as well as an outlook on possible future developments in …

Rethinking neuroprotection in severe traumatic brain injury: toward bedside neuroprotection

T Zoerle, M Carbonara, ER Zanier, F Ortolano… - Frontiers in …, 2017 - frontiersin.org
Neuroprotection after traumatic brain injury (TBI) is an important goal pursued strenuously in
the last 30 years. The acute cerebral injury triggers a cascade of biochemical events that …

Management of traumatic brain injury in the intensive care unit

GSF Ling, SA Marshall - Neurologic clinics, 2008 - Elsevier
Traumatic brain injury is a common and complex clinical entity that deserves better and
continued research on interventions and initial treatment postinjury. Current medical …

[HTML][HTML] Multifunctional drugs for head injury

R Vink, AJ Nimmo - Neurotherapeutics, 2009 - Elsevier
Traumatic brain injury (TBI) remains one of the leading causes of mortality and morbidity
worldwide in individuals under the age of 45 years, and, despite extensive efforts to develop …

Pharmacologic neuroprotection for functional outcomes after traumatic brain injury: a systematic review of the clinical literature

SE Gruenbaum, A Zlotnik, BF Gruenbaum, D Hersey… - CNS drugs, 2016 - Springer
Introduction Traumatic brain injury (TBI) is a major cause of death and disability worldwide.
The deleterious effects of secondary brain injury may be attenuated by early …