Brain white matter hyperintensities, executive dysfunction, instability, and falls in older people: a prospective cohort study

JJJ Zheng, SR Lord, JCT Close… - … Series A: Biomedical …, 2012 - academic.oup.com
Abstract Background. White matter hyperintensities (WMHs) are associated with fall risk
factors in older people including reduced cognitive functioning and impaired balance and …

White matter hyperintensities are associated with falls in older people with dementia

ME Taylor, SR Lord, K Delbaere, W Wen… - Brain imaging and …, 2019 - Springer
Abstract White Matter Hyperintensities (WMHs) are associated with impaired gait, balance
and cognition and increased fall risk in cognitively healthy older people. However, few …

Progression of white matter hyperintensities of presumed vascular origin increases the risk of falls in older people

ML Callisaya, R Beare, T Phan… - … Series A: Biomedical …, 2015 - academic.oup.com
Background. Greater volume of cerebral white matter hyperintensities (WMH) of presumed
vascular origin may affect postural control and gait. WMH measured at one time point …

The correlation between white matter hyperintensity and balance disorder and fall risk: An observational, prospective cohort study

DC Shen, SL Wu, YZ Shi, S Wang… - Chronic Diseases and …, 2016 - mednexus.org
Objective: The presence of an association between white matter hyperintensity (WMH) and
the risk of falls in older people is uncertain, with little supporting prospective evidence …

Mind the gaps: functional networks disrupted by white matter hyperintensities are associated with greater falls risk

RA Crockett, CL Hsu, E Dao, R Tam, W Alkeridy… - Neurobiology of …, 2022 - Elsevier
White matter hyperintensities (WMH) are associated with greater falls risk and slow gait
speed. Whether these deficits are caused by the disruption of large-scale functional …

White matter hyperintensities are an independent predictor of physical decline in community-dwelling older people

JJJ Zheng, K Delbaere, JCT Close, P Sachdev, W Wen… - Gerontology, 2012 - karger.com
Background: Ageing is associated with physical disability, but little is known about the
influence of white matter hyperintensities (WMHs) on physical function decline in older …

Functional impact of white matter hyperintensities in cognitively normal elderly subjects

ME Murray, ML Senjem, RC Petersen… - Archives of …, 2010 - jamanetwork.com
Objective To investigate the impact white matter hyperintensities (WMH) detected on
magnetic resonance imaging have on motor dysfunction and cognitive impairment in elderly …

Contributors to poor mobility in older adults: integrating white matter hyperintensities and conditions affecting other systems

AL Rosso, SA Studenski… - … Series A: Biomedical …, 2017 - academic.oup.com
Background Age-related mobility limitations are debilitating and common. Cerebral white
matter hyperintensities (WMH) and conditions affecting other systems are known …

Impact of white matter lesions on physical functioning and fall risk in older people: a systematic review

JJJ Zheng, K Delbaere, JCT Close, PS Sachdev… - Stroke, 2011 - Am Heart Assoc
Background and Purpose—White matter lesions (WMLs) are common findings on
neuroimaging in older people. This review systematically evaluates the published literature …

Frontal white matter hyperintensities and executive functioning performance in older adults

EM Boutzoukas, A O'Shea, A Albizu… - Frontiers in aging …, 2021 - frontiersin.org
Frontal lobe structures decline faster than most other brain regions in older adults. Age-
related change in the frontal lobe is associated with poorer executive function (eg, working …