OBJECTIVE: The authors reviewed the pathogenesis of cocaine-related cerebral ischemia,
appraised current knowledge of its sequelae, and assessed the role of putative therapeutic …

Cocaine abuse remains a devastating medical problem for our society. Current concepts
suggest that both hemorrhagic and ischemic stroke, particularly in young people, can result …

This paper will examine how cerebral perfusion deficits in cocaine abusers may be a target
for pharmacotherapy. The review covers five areas:(1) cerebral ischemia and …

Cocaine-associated stroke (CAS) is an important cause of disability, especially among
younger adults. Improved management has increased survival but little has been discussed …

Background: Cocaine and its metabolites can produce vasospasm. Cocaine-dependent
(CD) patients are at increased risk for stroke, and a high frequency of brain perfusion defects …

The L-type calcium channel antagonist, isradipine, reduces brain ischemia in animal models
of ischemic stroke. These effects of isradipine appear more pronounced in dopamine (DA) …

Stroke is the third most common cause of death in developed countries. In England and
Wales, 1000 people under the age of 30 have a stroke each year. Cocaine is the most …

Research indicates that cocaine significantly constricts the cerebral vasculature and can
lead to ischemic brain infarction. Long-term effects of intermittent or casual cocaine use in …

Cocaine use is associated with ischemic stroke through unique mechanisms, including
reversible vasospasm, drug-induced arteritis, enhanced platelet aggregation …

Cocaine, especially in its alkaloidal or “crack” form, has been increasingly associated with
cerebrovascular disease. Before the crack epidemic, cocaine hydrochloride (HCl) was also …