In Situ Liquid‐Cell TEM Observation of Multiphase Classical and Nonclassical Nucleation of Calcium Oxalate

DJ Banner, E Firlar, P Rehak… - Advanced Functional …, 2021 - Wiley Online Library
Calcium oxalate (CaOx) is the major phase in kidney stones and the primary calcium
storage medium in plants. CaOx can form crystals with different lattice types, water contents …

Understanding the role of citric acid on the crystallization pathways of calcium oxalate hydrates

S Li, W Tang, M Li, L Wang, Y Yang… - Crystal Growth & …, 2019 - ACS Publications
The precipitation of calcium oxalate can be either grown into structural support in plants or
precipitated as stones in human kidneys. Previously, citrate, an effective inhibitor for oxalate …

A new perspective of gallic acid on calcium oxalate nucleation

S Li, W Tang, P Shi, M Li, J Sun… - Crystal Growth & Design, 2020 - ACS Publications
The therapeutics for nephrolithiasis have created an awareness of the potential effects of
crystal modifiers on the biocrystallization process. The crystallization of calcium oxalate, a …

Cooperative effects of Na+ and citrates on the dissolution of calcium oxalate crystals

M Shanthil, K Sandeep, PK Sajith - Physical Chemistry Chemical …, 2020 - pubs.rsc.org
Precipitation and dissolution of calcium oxalate monohydrate (CaOx) crystals are relevant
due to their major role in kidney stone diseases. To such an extent, small molecules and …

Role of hyperoxaluria/hypercalciuria in controlling the hydrate phase selection of pathological calcium oxalate mineralization

J Zhang, L Wang, W Zhang, CV Putnis - Crystal growth & design, 2020 - ACS Publications
Both clinical observations and in vitro studies have confirmed that hyperoxaluria or
hypercalciuria is one of the main factors that determine the phase formation of pathological …

Quantitative analysis of calcium oxalate monohydrate and dihydrate for elucidating the formation mechanism of calcium oxalate kidney stones

M Maruyama, KP Sawada, Y Tanaka, A Okada… - PLoS …, 2023 - journals.plos.org
We sought to identify and quantitatively analyze calcium oxalate (CaOx) kidney stones on
the order of micrometers, with a focus on the quantitative identification of calcium oxalate …

Modulation of the calcium oxalate dihydrate to calcium oxalate monohydrate phase transition with citrate and zinc ions

J Zhang, W Zhang, CV Putnis, L Wang - CrystEngComm, 2021 - pubs.rsc.org
As one of the most ubiquitous biominerals, calcium oxalate (CaOx) exhibits different hydrate
phases. Although the monohydrate (whewellite, COM) is the thermodynamically favorable …

Mechanistic pathways for the molecular step growth of calcium oxalate monohydrate crystal revealed by in situ liquid-phase atomic force microscopy

KR Cho, JH Lee, HS Seo, Y Ji, JH Park… - … Applied Materials & …, 2021 - ACS Publications
Calcium oxalate monohydrate (COM) crystal is the most common crystalline component of
human kidney stones. The molecular-scale inhibitory mechanisms of COM crystal growth by …

In situ liquid SAXS studies on the early stage of calcium carbonate formation

ASA Mohammed, A Carino, A Testino… - Particle & Particle …, 2019 - Wiley Online Library
Calcium carbonate is a model system to investigate the mechanism of solid formation by
precipitation from solutions, and it is often considered in the debated classical and …

Citrate modulates calcium oxalate crystal growth by face-specific interactions

B Grohe, J O'Young, A Langdon, M Karttunen… - Cells Tissues …, 2011 - karger.com
Because of its ability to inhibit the growth of calcium oxalate monohydrate (COM) crystals,
citrate plays an important role in preventing the formation of kidney stones. To determine the …