Alzheimer's disease is the most prevalent type of dementia and is caused by the deposition
of extracellular amyloid‐beta and abnormal tau phosphorylation. Neuroinflammation has …

Activation of the inflammasome is implicated in the pathogenesis of an increasing number of
inflammatory diseases, including Alzheimer's disease (AD). Research reporting …

Innate immunity and inflammatory response plays an important role in the pathogenesis of
Alzheimer's disease (AD). As the major resident immune cells in the brain, microglial cells …

Alzheimer's disease (AD) is the most prevalent form of late-onset dementia. AD affects the
health of millions of people in the United States and worldwide. Currently, there are no …

Neuroinflammation contributes to Alzheimer's disease (AD) progression. Secondary
inflammatory insults trigger delirium and can accelerate cognitive decline. Individual cellular …

Neuroinflammatory responses in Alzheimer's disease (AD) are complex and not fully
understood. They involve various cellular and molecular players and associate interaction …

Alzheimer's disease (AD) is a common neurodegenerative disease of progressive dementia
which is characterized pathologically by extracellular neuritic plaques containing …

Highlights•Aβ 1− 42-induced NLRP3 inflammasome activation in BV-2 microglia is mediated
through TLR4.•TLR4/NLRP3 signaling plays a critical role in Aβ 1− 42-induced …

Highlights•Host-derived molecules (eg β-amyloid, tau) trigger NLRP3 inflammasome
signaling.•TNF, ATP, serum amyloid A and the microbiome regulate NLRP3 inflammasome …

Numerous studies demonstrate that neuroinflammation is a key player in the progression of
Alzheimer's disease (AD). Interleukin (IL)-1β is a main inducer of inflammation and therefore …