Cellular uptake and fate of PEGylated gold nanoparticles is dependent on both cell-penetration peptides and particle size

E Oh, JB Delehanty, KE Sapsford, K Susumu… - ACS …, 2011 - ACS Publications
Numerous studies have examined how the cellular delivery of gold nanoparticles (AuNPs) is
influenced by different physical and chemical characteristics; however, the complex …

Peptide modified gold nanoparticles for improved cellular uptake, nuclear transport, and intracellular retention

C Yang, J Uertz, D Yohan, BD Chithrani - Nanoscale, 2014 - pubs.rsc.org
Gold nanoparticles (GNPs) are being extensively used in cancer therapeutic applications
due to their ability to act both as an anticancer drug carrier in chemotherapy and as a dose …

A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands

X Huang, X Peng, Y Wang, Y Wang, DM Shin… - ACS …, 2010 - ACS Publications
The targeted delivery of nanoparticles to solid tumors is one of the most important and
challenging problems in cancer nanomedicine, but the detailed delivery mechanisms and …

Cellular trajectories of peptide-modified gold particle complexes: comparison of nuclear localization signals and peptide transduction domains

AG Tkachenko, H Xie, Y Liu, D Coleman… - Bioconjugate …, 2004 - ACS Publications
Gold nanoparticles modified with nuclear localization peptides were synthesized and
evaluated for their subcellular distribution in HeLa human cervical epithelium cells, 3T3/NIH …

Cellular uptake of gold nanoparticles triggered by host–guest interactions

J Mosquera, M Henriksen-Lacey, I García… - Journal of the …, 2018 - ACS Publications
We describe an approach to regulate the cellular uptake of small gold nanoparticles using
supramolecular chemistry. The strategy relies on the functionalization of AuNPs with …

Biologically inspired stealth peptide-capped gold nanoparticles

AK Nowinski, AD White, AJ Keefe, S Jiang - Langmuir, 2014 - ACS Publications
Introduction into the human body makes most nanoparticle systems susceptible to
aggregation via nonspecific protein binding. Here, we developed a peptide-capped gold …

Mammalian Cells Exocytose Alkylated Gold Nanoparticles via Extracellular Vesicles

LWC Ho, CKW Chan, R Han, YFY Lau, H Li, YP Ho… - ACS …, 2022 - ACS Publications
Understanding the exocytosis of nanoparticles (NPs) from cells is valuable because it
informs design rules of NPs that support desirable cellular retention for nanomedicine …

Synthesis, stability, and cellular internalization of gold nanoparticles containing mixed peptide− poly (ethylene glycol) monolayers

Y Liu, MK Shipton, J Ryan, ED Kaufman… - Analytical …, 2007 - ACS Publications
Gold nanoparticles have shown great promise as therapeutics, therapeutic delivery vectors,
and intracellular imaging agents. For many biomedical applications, selective cell and …

Effect of alkylation on the cellular uptake of polyethylene glycol-coated gold nanoparticles

LWC Ho, WY Yung, KHS Sy, HY Li, CKK Choi… - ACS …, 2017 - ACS Publications
Alkyl groups (C n H2 n+ 1) are prevalent in engineered bionanomaterials used for many
intracellular applications, yet how alkyl groups dictate the interactions between …

Multiplexed screening of cellular uptake of gold nanoparticles using laser desorption/ionization mass spectrometry

ZJ Zhu, PS Ghosh, OR Miranda… - Journal of the …, 2008 - ACS Publications
Gold nanoparticles (AuNPs) are highly promising candidates as drug delivery agents into
cells of interest. We describe for the first time the multiplexed analysis of nanoparticle uptake …