Introduction Human zona pellucida (ZP) plays an important role in reproductive process.
Several rare mutations in the encoding genes (ZP1, ZP2, and ZP3) have been demonstrated …

The human zona pellucida (ZP) is an extracellular glycoprotein matrix composed of ZP1,
ZP2, ZP3, and ZP4 surrounding the oocyte, and it plays an important role in sperm–egg …

Background The zona pellucida (ZP) of human oocytes plays essential protective roles in
sperm–egg interactions during fertilisation and embryo development. ZP4-null female …

Purpose We aimed to identify pathogenic variants in two infertile sisters in a family with a
thin zona pellucida (ZP) phenotype. Methods Whole-exome sequencing was performed in …

The human zona pellucida (ZP) is a highly organized glycoprotein matrix that encircles
oocytes and plays an essential role in successful reproduction. Previous studies have …

Purpose The aim of this study was to identify the disease-causing mutations found in three
infertile female patients who were diagnosed with abnormal zona pellucida (ZP) and empty …

Purpose To identify disease-causing genes involved in female infertility. Methods Whole-
exome sequencing and Sanger DNA sequencing were used to identify the mutations in …

Background In mammals, normal fertilization depends on the structural and functional
integrity of the zona pellucida (ZP), which is an extracellular matrix surrounding oocytes …

The zona pellucida (ZP) is an extracellular glycoprotein matrix surrounding mammalian
oocytes. Recently, numerous mutations in genes encoding ZP proteins have been shown to …

Lack of the zona pellucida (ZP) is one of the manifestations of an oocyte maturation disorder.
In recent years, genetic factors have attracted much attention as a possible cause of ZP …