Updates and advances in multiple sclerosis neurotherapeutics

M Amin, CM Hersh - Neurodegenerative disease management, 2023 - Taylor & Francis
The multiple sclerosis (MS) neurotherapeutic landscape is rapidly evolving. New disease-
modifying therapies (DMTs) with improved efficacy and safety, in addition to an expanding …

Updates on efficacy and safety outcomes of new and emerging disease modifying therapies and stem cell therapy for Multiple Sclerosis: A review

S Peterson, A Jalil, K Beard, M Kakara… - Multiple Sclerosis and …, 2022 - Elsevier
Multiple Sclerosis (MS) is a chronic neurodegenerative autoimmune disorder of the central
nervous system (CNS) and the most common cause of serious physical disability in working …

Failed, interrupted, or inconclusive trials on neuroprotective and neuroregenerative treatment strategies in multiple sclerosis: update 2015–2020

N Huntemann, L Rolfes, M Pawlitzki, T Ruck, S Pfeuffer… - Drugs, 2021 - Springer
In the recent past, a plethora of drugs have been approved for the treatment of multiple
sclerosis (MS). These therapeutics are mainly confined to immunomodulatory or …

Therapies for multiple sclerosis: translational achievements and outstanding needs

A Haghikia, R Hohlfeld, R Gold, L Fugger - Trends in Molecular Medicine, 2013 - cell.com
In recent years, multiple sclerosis (MS) research has progressed on several fronts,
prompting numerous clinical trials, primarily for immunotherapeutics. Although several new …

Achievements and obstacles of remyelinating therapies in multiple sclerosis

M Stangel, T Kuhlmann, PM Matthews… - Nature Reviews …, 2017 - nature.com
Remyelination in the CNS is the natural process of damage repair in demyelinating
diseases such as multiple sclerosis (MS). However, remyelination becomes inadequate in …

Stem cell therapies for progressive multiple sclerosis

JA Smith, AM Nicaise, RB Ionescu, R Hamel… - Frontiers in cell and …, 2021 - frontiersin.org
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
characterized by demyelination and axonal degeneration. MS patients typically present with …

Stem cell-based therapies for multiple sclerosis: current perspectives

FX Cuascut, GJ Hutton - Biomedicines, 2019 - mdpi.com
Multiple sclerosis (MS) is an inflammatory and neurodegenerative autoimmune disease of
the central nervous system (CNS). Disease-modifying therapies (DMT) targeting …

New and emerging disease modifying therapies for multiple sclerosis

S Saidha, C Eckstein… - Annals of the New York …, 2012 - Wiley Online Library
Several disease‐modifying drugs (DMDs) are currently approved for the treatment of
multiple sclerosis (MS). Recently, there has been increased identification and development …

Neuroprotection, regeneration and immunomodulation: broadening the therapeutic repertoire in multiple sclerosis

O Aktas, B Kieseier, HP Hartung - Trends in neurosciences, 2010 - cell.com
Multiple sclerosis (MS), an incurable but manageable disorder, is characterized by chronic
inflammatory demyelination and neurodegeneration in the central nervous system. Although …

Toward the development of rational therapies in multiple sclerosis: what is on the horizon?

B Hemmer, HP Hartung - Annals of neurology, 2007 - Wiley Online Library
Although the cause of multiple sclerosis (MS) has remained obscure, many findings support
an autoimmune pathogenesis on the background of a complex interaction between multiple …