Pathogenicity and virulence of African trypanosomes: From laboratory models to clinically relevant hosts

LJ Morrison, PC Steketee, MD Tettey, KR Matthews - Virulence, 2023 - Taylor & Francis
African trypanosomes are vector-borne protozoa, which cause significant human and animal
disease across sub-Saharan Africa, and animal disease across Asia and South America. In …

The within-host dynamics of African trypanosome infections

KR Matthews, R McCulloch… - … Transactions of the …, 2015 - royalsocietypublishing.org
African trypanosomes are single-celled protozoan parasites that are capable of long-term
survival while living extracellularly in the bloodstream and tissues of mammalian hosts …

Murine Models for Trypanosoma brucei gambiense Disease Progression—From Silent to Chronic Infections and Early Brain Tropism

C Giroud, F Ottones, V Coustou… - PLoS Neglected …, 2009 - journals.plos.org
Background Human African trypanosomiasis (HAT) caused by Trypanosoma brucei
gambiense remains highly prevalent in west and central Africa and is lethal if left untreated …

[图书][B] Trypanosomes and trypanosomiasis

S Magez, M Radwanska - 2014 - Springer
'Trypanosomiasis' in general refers to a collection of parasitic diseases caused by both
extracellular and intracellular protozoan parasites. This book will focus mainly on the …

African trypanosomes in the 21st century: what is their future in science and in health?

GAM Cross - International journal for parasitology, 2001 - Elsevier
The African trypanosomes remain well recognised for their role as an interesting model
eukaryote for basic science, but are loosing ground in their ability to contribute to …

Escape mechanisms of African trypanosomes: why trypanosomosis is keeping us awake

J Cnops, S Magez, C De Trez - Parasitology, 2015 - cambridge.org
African trypanosomes have been around for more than 100 million years, and have adapted
to survival in a very wide host range. While various indigenous African mammalian host …

Specializations in a successful parasite: what makes the bloodstream-form African trypanosome so deadly?

C Gadelha, JM Holden, HC Allison, MC Field - Molecular and biochemical …, 2011 - Elsevier
Most trypanosomatid parasites have both arthropod and mammalian or plant hosts, and the
ability to survive and complete a developmental program in each of these very different …

Mouse models for pathogenic African trypanosomes: unravelling the immunology of host–parasite–vector interactions

S Magez, G Caljon - Parasite Immunology, 2011 - Wiley Online Library
African trypanosomiasis is a parasitic disease that affects a variety of mammals, including
humans, on the sub‐Saharan African continent. To understand the diverse parameters that …

Contributions of experimental mouse models to the understanding of African trypanosomiasis

N Antoine-Moussiaux, S Magez, D Desmecht - Trends in Parasitology, 2008 - cell.com
African trypanosomiasis is the collective name for a wide variety of trypanosome infections
that affect humans and livestock. In recent years, experimental mice infection models have …

African trypanosomes undermine humoral responses and vaccine development: link with inflammatory responses?

B Stijlemans, M Radwanska, C De Trez… - Frontiers in …, 2017 - frontiersin.org
African trypanosomosis is a debilitating disease of great medical and socioeconomical
importance. It is caused by strictly extracellular protozoan parasites capable of infecting all …