Treatment trials in young patients with chronic obstructive pulmonary disease and pre–chronic obstructive pulmonary disease patients: time to move forward

FJ Martinez, A Agusti, BR Celli, MLK Han… - American journal of …, 2022 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is the end result of a series of dynamic and
cumulative gene–environment interactions over a lifetime. The evolving understanding of …

At the root: defining and halting progression of early chronic obstructive pulmonary disease

FJ Martinez, MLK Han, JP Allinson, RG Barr… - American journal of …, 2018 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is a prevalent, heterogeneous disorder with
varying presentation and progression but with a limited number of disease-modifying …

COPD: a pediatric disease

A Bush - COPD: Journal of chronic obstructive pulmonary …, 2008 - Taylor & Francis
Chronic obstructive pulmonary disease (COPD) is conventionally thought of as a disease of
adult smokers, related to airway inflammation and structural airway changes (remodeling) …

Early origins of chronic obstructive pulmonary disease

I Narang, A Bush - Seminars in fetal and neonatal medicine, 2012 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality
worldwide and a significant challenge for adult physicians. However, there is a …

Early life influences on the development of chronic obstructive pulmonary disease

J Stocks, S Sonnappa - Therapeutic advances in respiratory …, 2013 - journals.sagepub.com
There is increasing evidence that chronic obstructive pulmonary disease (COPD) is not
simply a disease of old age that is largely restricted to heavy smokers, but may be …

Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study

LP Hayden, BD Hobbs, RT Cohen, RA Wise… - Respiratory …, 2015 - Springer
Background Development of adult respiratory disease is influenced by events in childhood.
The impact of childhood pneumonia on chronic obstructive pulmonary disease (COPD) is …

What is early COPD and why is it important?

JB Soriano, F Polverino… - European Respiratory …, 2018 - Eur Respiratory Soc
There is increasing interest in the origins of chronic obstructive pulmonary disease (COPD),
as it is envisaged that preventive efforts and treatment can modify its clinical course. The …

Chronic obstructive pulmonary disease phenotypes: the future of COPD

MLK Han, A Agusti, PM Calverley, BR Celli… - American journal of …, 2010 - atsjournals.org
Significant heterogeneity of clinical presentation and disease progression exists within
chronic obstructive pulmonary disease (COPD). Although FEV1 inadequately describes this …

Future research directions in chronic obstructive pulmonary disease

TL Croxton, GG Weinmann, RM Senior… - American journal of …, 2002 - atsjournals.org
Between 3 and 7 million Americans are currently diagnosed with chronic obstructive
pulmonary disease (COPD), and the true prevalence is probably greater than 16 million (1) …

Update on clinical aspects of chronic obstructive pulmonary disease

BR Celli, JA Wedzicha - New England Journal of Medicine, 2019 - Mass Medical Soc
Update on Clinical Aspects of Chronic Obstructive Pulmonary Disease | New England Journal of
Medicine Skip to main content The New England Journal of Medicine homepage Advanced …