Metabolically quiescent pathogens can persist in a viable non-replicating state for months or
even years. For certain infectious diseases, such as tuberculosis, cryptococcosis …

Cryptococcosis is an opportunistic infection due to the ubiquitous yeast Cryptococcus
neoformans. This yeast interacts closely with innate immune cells, leading to various fates …

Cryptococcus neoformans is an opportunistic yeast that is present worldwide and interacts
with various organisms. In humans, it is responsible for cryptococcosis, a deadly invasive …

Although several virulence factors and associated genes have been identified, the
mechanisms that allow Cryptococcus neoformans to adapt during chronic infection and to …

Cryptococcus neoformans is an environmental yeast that is a leading cause of fatal mycosis
in AIDS patients and a major cause of meningoencephalitis and CNS-related mortality …

Mitochondria are essential organelles that act in pathways including ATP production, β-
oxidation, and clearance of reactive oxygen species. They occur as a complex reticular …

Upon Cryptococcus neoformans infection of the host lung, the fungus enters a nutrient poor
environment and must adapt to a variety of host-specific stress conditions (temperature …

Does cell age matter in virulence? The emergence of persister cells during chronic
infections is critical for persistence of infection, but little is known how this occurs. Here, we …

A common feature shared by systemic fungal pathogens of environmental origin, such as
Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In …

Amoeboid predators, such as amoebae, are proposed to select for survival traits in soil
microbes such as Cryptococcus neoformans; these traits can also function in animal …