Amoeba predation of Cryptococcus neoformans results in pleiotropic changes to traits associated with virulence

MS Fu, LC Liporagi-Lopes, SR dos Santos, JL Tenor… - MBio, 2021 - Am Soc Microbiol
Amoeboid predators, such as amoebae, are proposed to select for survival traits in soil
microbes such as Cryptococcus neoformans; these traits can also function in animal …

[HTML][HTML] Dangerous Liaisons: Interactions of Cryptococcus neoformans with Host Phagocytes

EA Gaylord, HL Choy, TL Doering - Pathogens, 2020 - mdpi.com
Cryptococcus neoformans is an opportunistic fungal pathogen and a leading cause of death
in immunocompromised individuals. The interactions of this yeast with host phagocytes are …

The Intracellular Life of Cryptococcus neoformans

C Coelho, AL Bocca… - Annual Review of …, 2014 - annualreviews.org
Cryptococcus neoformans is a fungal pathogen with worldwide distribution. Serological
studies of human populations show a high prevalence of human infection, which rarely …

Genetic analysis of Hsp90 function in Cryptococcus neoformans highlights key roles in stress tolerance and virulence

C Fu, SR Beattie, AJ Jezewski, N Robbins… - Genetics, 2022 - academic.oup.com
The opportunistic human fungal pathogen Cryptococcus neoformans has tremendous
impact on global health, causing 181,000 deaths annually. Current treatment options are …

[HTML][HTML] 'Division of labour' in response to host oxidative burst drives a fatal Cryptococcus gattii outbreak

K Voelz, SA Johnston, LM Smith, RA Hall… - Nature …, 2014 - nature.com
Cryptococcus gattii is an emerging intracellular pathogen and the cause of the largest
primary outbreak of a life-threatening fungal disease in a healthy population. Outbreak …

The tools for virulence of Cryptococcus neoformans

C Coelho, AL Bocca, A Casadevall - Advances in applied microbiology, 2014 - Elsevier
Cryptococcus neoformans is a fungal pathogen that causes almost half a million deaths
each year. It is believed that most humans are infected with C. neoformans, possibly in a …

[HTML][HTML] Modulation of Replicative Lifespan in Cryptococcus neoformans: Implications for Virulence

T Bouklas, N Jain, BC Fries - Frontiers in microbiology, 2017 - frontiersin.org
The fungal pathogen, Cryptococcus neoformans, has been shown to undergo replicative
aging. Old cells are characterized by advanced generational age and phenotypic changes …

Macrophage mitochondrial and stress response to ingestion of Cryptococcus neoformans

C Coelho, ACO Souza, LS Derengowski… - The Journal of …, 2015 - journals.aai.org
Human infection with Cryptococcus neoformans, a common fungal pathogen, follows
deposition of yeast spores in the lung alveoli. The subsequent host–pathogen interaction …

Expanding fungal pathogenesis: Cryptococcus breaks out of the opportunistic box

JW Kronstad, R Attarian, B Cadieux, J Choi… - Nature reviews …, 2011 - nature.com
Cryptococcus neoformans is generally considered to be an opportunistic fungal pathogen
because of its tendency to infect immunocompromised individuals, particularly those …

The Cyclin Cln1 Controls Polyploid Titan Cell Formation following a Stress-Induced G2 Arrest in Cryptococcus

S Altamirano, Z Li, MS Fu, M Ding, SR Fulton, JM Yoder… - Mbio, 2021 - Am Soc Microbiol
The pathogenic yeast Cryptococcus neoformans produces polyploid titan cells in response
to the host lung environment that are critical for host adaptation and subsequent disease …