Whole Genome Sequence Analysis of Cryptococcus gattii from the Pacific Northwest Reveals Unexpected Diversity

JD Gillece, JM Schupp, SA Balajee, J Harris… - PLoS …, 2011 - journals.plos.org
A recent emergence of Cryptococcus gattii in the Pacific Northwest involves strains that fall
into three primarily clonal molecular subtypes: VGIIa, VGIIb and VGIIc. Multilocus sequence …

Cryptococcus gattii in the United States: Genotypic Diversity of Human and Veterinary Isolates

SR Lockhart, N Iqbal, JR Harris, NT Grossman… - PloS one, 2013 - journals.plos.org
Background Cryptococcus gattii infections are being reported in the United States (US) with
increasing frequency. Initially, US reports were primarily associated with an ongoing C. gattii …

Comparative Gene Genealogies Indicate that Two Clonal Lineages of Cryptococcus gattii in British Columbia Resemble Strains from Other Geographical Areas

SE Kidd, H Guo, KH Bartlett, J Xu, JW Kronstad - Eukaryotic Cell, 2005 - Am Soc Microbiol
Cryptococcus gattii has recently emerged as a pathogen of humans and animals in the
temperate climate of Vancouver Island, British Columbia (BC). The majority (∼ 95%) of the …

Cryptococcus gattii in North American Pacific Northwest: whole-population genome analysis provides insights into species evolution and dispersal

DM Engelthaler, ND Hicks, JD Gillece, CC Roe… - MBio, 2014 - Am Soc Microbiol
The emergence of distinct populations of Cryptococcus gattii in the temperate North
American Pacific Northwest (PNW) was surprising, as this species was previously thought to …

Emergence and Pathogenicity of Highly Virulent Cryptococcus gattii Genotypes in the Northwest United States

EJ Byrnes III, W Li, Y Lewit, H Ma, K Voelz, P Ren… - PLoS …, 2010 - journals.plos.org
Cryptococcus gattii causes life-threatening disease in otherwise healthy hosts and to a
lesser extent in immunocompromised hosts. The highest incidence for this disease is on …

Cryptococcus gattii in the age of whole-genome sequencing

W Meyer - MBio, 2015 - Am Soc Microbiol
Cryptococcus gattii, the sister species of Cryptococcus neoformans, is an emerging
pathogen which gained importance in connection with the ongoing cryptococcosis outbreak …

Copy number variation contributes to cryptic genetic variation in outbreak lineages of Cryptococcus gattii from the North American Pacific Northwest

JL Steenwyk, JS Soghigian, JR Perfect, JG Gibbons - BMC genomics, 2016 - Springer
Abstract Background Copy number variants (CNVs) are a class of structural variants (SVs)
and are defined as fragments of DNA that are present at variable copy number in …

MLST and Whole-Genome-Based Population Analysis of Cryptococcus gattii VGIII Links Clinical, Veterinary and Environmental Strains, and Reveals Divergent …

C Firacative, CC Roe, R Malik… - PLoS Neglected …, 2016 - journals.plos.org
The emerging pathogen Cryptococcus gattii causes life-threatening disease in
immunocompetent and immunocompromised hosts. Of the four major molecular types (VGI …

[HTML][HTML] Cryptococcus gattii infections in multiple states outside the US Pacific Northwest

JR Harris, SR Lockhart, G Sondermeyer… - Emerging infectious …, 2013 - ncbi.nlm.nih.gov
Clonal VGII subtypes (outbreak strains) of Cryptococcus gattii have caused an outbreak in
the US Pacific Northwest since 2004. Outbreak-associated infections occur equally in male …

Phylogenomic Placement of American Southwest-Associated Clinical and Veterinary Isolates Expands Evidence for Distinct Cryptococcus gattii VGVI

J Monroy-Nieto, JR Bowers, P Montfort, G Adame… - Microorganisms, 2022 - mdpi.com
Whole-genome sequencing has advanced our understanding of the population structure of
the pathogenic species complex Cryptococcus gattii, which has allowed for the …