An integral challenge in synthetic circuit design is the selection of optimal parts to populate a
given circuit topology, so that the resulting circuit behavior best approximates the desired …

Automatic design of synthetic gene circuits poses a significant challenge to synthetic
biology, primarily due to the complexity of biological systems, and the lack of rigorous …

Motivation: The design of de novo circuits with predefined performance specifications is a
challenging problem in Synthetic Biology. Computational models and tools have proved to …

The rational design of synthetic gene circuits has led to many successful applications over
the past decade. However, increasingly complex constructs also revealed that analogies to …

Synthetic circuits offer great promise for generating insights into nature's underlying design
principles or forward engineering novel biotechnology applications. However, construction …

The aim of synthetic biology is to confer novel functions to cells by rationally interconnecting
basic genetic parts into circuits. A key barrier in the design of synthetic genetic circuits is that …

Genetic design automation methods for combinational circuits often rely on standard
algorithms from electronic design automation in their circuit synthesis and technology …

In the first wave of synthetic biology, genetic elements, combined into simple circuits, are
used to control individual cellular functions. In the second wave of synthetic biology, the …

De novo computational design of synthetic gene circuits that achieve well-defined target
functions is a hard task. Existing, brute-force approaches run optimization algorithms on the …

One major direction in synthetic biology involves the redesign of biological systems and
components to acquire new properties and abilities. The last two decades have seen …