Heart contraction vitally depends on tightly controlled intracellular Ca regulation. Because
contraction is mainly driven by Ca released from the sarcoplasmic reticulum (SR), this …

Abstract Type 2 ryanodine receptor (RyR2) serves as the major intracellular Ca 2+ release
channel that drives heart contraction. RyR2 is activated by cytosolic Ca 2+ via the process of …

Abnormal cardiac ryanodine receptor (RyR2) function is recognized as an important factor in
the pathogenesis of heart failure (HF). However, the specific molecular causes underlying …

The cardiac ryanodine receptor (RyR2), a Ca2+ release channel on the membrane of the
sarcoplasmic reticulum (SR), plays a key role in determining the strength of the heartbeat by …

Oxidative stress may contribute to cardiac ryanodine receptor (RyR2) dysfunction in heart
failure (HF) and arrhythmias. Altered RyR2 domain–domain interaction (domain unzipping) …

Rationale Heart failure is a multimodal disorder, of which disrupted Ca 2+ homeostasis is a
hallmark. Central to Ca 2+ homeostasis is the major cardiac Ca 2+ release channel–the …

Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood
to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ …

Cardiac ryanodine receptor type 2 plays a key role in excitation–contraction coupling. The
ryanodine receptor type 2 channel protein is modulated by various post-translational …

Calcium dependent signaling is highly regulated in cardiomyocytes and determines the
force of cardiac muscle contraction. The cardiac ryanodine receptors (RyR2) play important …

In cardiac muscle, the ryanodine receptor (RyR2) on the sarcoplasmic reticulum (SR)
releases the calcium required for muscle contraction. The magnitude of Ca 2+ release by …