The digoxin-quinidine interaction was studied in nine healthy human subjects aged 26 to 31
years. A single oral dose (400 mg) of quinidine sulfate administered to subjects taking …

Digoxin concentrations in serum, myocardium, 3 separate skeletal muscles, kidney, liver,
and 5 sites in the brain were measured in 26 dogs given 12-alpha 3 H-digoxin. Ten of the …

Systolic time intervals (QS 2-I and LVET-I) and echocardiographically determined ejection
fraction and velocity of circumferential fiber shortening were recorded in 10 healthy …

Cardioactivity due to elevated serum digoxin concentration (SDC) after quinidine (Q) and
digoxin (D) was evaluated in six healthy subjects by means of measurement of systolic time …

The effects of the digoxin‐quinidine interaction on cardiac function was examined in healthy
subjects. Our results indicate that while serum digoxin levels were elevated, the improved …

Quinidine elevates serum digoxin concentration in part by reducing the volume of
distribution of digoxin, which implies that quinidine displaces digoxin from tissues. The …

Following the development of digoxin radioimmunoassay, we noted that serum digoxin
concentrations appeared to rise in patients given quinidine. To further evaluate this …

The time course of the rise in serum digoxin concentration was followed in 18 patients
treated with digoxin as quinidine treatment was started with a loading dose. The mean …

The administration of quinidine to patients receiving digoxin maintenance therapy results in
a marked increase in the serum/plasma digoxin concentration. With over 90% of patients …

Quinidine causes an increase in the serum digoxin concentration. Three patients were
studied to determine if the increase in serum concentration is paralleled by an increase in …