[PDF][PDF] Anticancer drugs as potential inhibitors of AcrAB-TolC of multidrug resistant Escherichia coli: an in silico molecular modeling and docking study
ABSTRACT Objective: Overexpression of AcrAB-TolC protein complex is often associated
with the virulence of multidrug-resistant bacteria. Development of an effective efflux pump …
with the virulence of multidrug-resistant bacteria. Development of an effective efflux pump …
The search of potential inhibitors of the AcrAB–TolC system of multidrug-resistant Escherichia coli: an in silico approach
The number of infections caused by multidrug antibiotic resistance (MDR) species is
increasing globally. The efflux pump system, AcrAB–TolC, confers Escherichia coli …
increasing globally. The efflux pump system, AcrAB–TolC, confers Escherichia coli …
3D-Pharmacophore and Molecular Docking Studies for AcrAB-TolC Efflux Pump Potential Inhibitors from DrugBank and Traditional Chinese Medical Database
TV Phan - Open Access Macedonian Journal of Medical Sciences, 2022 - oamjms.eu
Background: Due to the widespread resistance to several antibiotics, the AcrAB-TolC
tripartite efflux pump is the primary multi-drug efflux system of Escherichia coli. One of the …
tripartite efflux pump is the primary multi-drug efflux system of Escherichia coli. One of the …
Discovery of AcrAB-TolC pump inhibitors: Virtual screening and molecular dynamics simulation approach
TV Phan, VTV Nguyen, CHH Nguyen… - Journal of …, 2023 - Taylor & Francis
AcrAB-TolC tripartite efflux pump, which belongs to the RND superfamily, is a main multi-
drug efflux system of Escherichia coli (E. coli) because of the broad resistance on various …
drug efflux system of Escherichia coli (E. coli) because of the broad resistance on various …
Combined Structure- and Ligand-Based Approach for the Identification of Inhibitors of AcrAB-TolC in Escherichia coli
The inhibition of efflux pumps is a promising approach to combating multidrug-resistant
bacteria. We have developed a combined structure-and ligand-based model, using …
bacteria. We have developed a combined structure-and ligand-based model, using …
Targeting outer membrane protein component AdeC for the discovery of efflux pump inhibitor against AdeABC efflux pump of multidrug resistant Acinetobacter …
P Verma, V Tiwari - Cell Biochemistry and Biophysics, 2018 - Springer
The structure and functioning of multidrug efflux systems provide us with a better
understanding of the transport of various antibiotics, thus giving a path for the discovery of …
understanding of the transport of various antibiotics, thus giving a path for the discovery of …
Identification of Natural Compound Inhibitors for Multidrug Efflux Pumps of Escherichia coli and Pseudomonas aeruginosa Using In Silico High-Throughput Virtual Screening …
V Aparna, K Dineshkumar, N Mohanalakshmi… - PloS one, 2014 - journals.plos.org
Pseudomonas aeruginosa and Escherichia coli are resistant to wide range of antibiotics
rendering the treatment of infections very difficult. A main mechanism attributed to the …
rendering the treatment of infections very difficult. A main mechanism attributed to the …
Discovering targeted inhibitors for Escherichia coli efflux pump fusion proteins using computational and structure‐guided approaches
SS Chauhan, A Gupta, A Srivastava… - Journal of …, 2024 - Wiley Online Library
Multidrug resistance pathogens causing infections and illness remain largely untreated
clinically. Efflux pumps are one of the primary processes through which bacteria develop …
clinically. Efflux pumps are one of the primary processes through which bacteria develop …
Binding site feature description of 2-substituted benzothiazoles as potential AcrAB-TolC efflux pump inhibitors in E. coli
The resistance-nodulation-division (RND) family efflux pumps are important in the antibiotic
resistance of Gram-negative bacteria. However, although a number of bacterial RND efflux …
resistance of Gram-negative bacteria. However, although a number of bacterial RND efflux …
[HTML][HTML] Required criteria of drug efflux pump inhibitors to disrupt the function of AcrB subunit protein from AcrAB-TolC multidrug efflux pump from Escherichia coli
R Alenazy - Journal of King Saud University-Science, 2024 - Elsevier
The infections of multidrug-resistant bacteria, particularly the infections caused by Gram-
negative bacterial infections, are considered the main global serious health problems …
negative bacterial infections, are considered the main global serious health problems …