ABSTRACT Objective: Overexpression of AcrAB-TolC protein complex is often associated
with the virulence of multidrug-resistant bacteria. Development of an effective efflux pump …

The number of infections caused by multidrug antibiotic resistance (MDR) species is
increasing globally. The efflux pump system, AcrAB–TolC, confers Escherichia coli …

Background: Due to the widespread resistance to several antibiotics, the AcrAB-TolC
tripartite efflux pump is the primary multi-drug efflux system of Escherichia coli. One of the …

AcrAB-TolC tripartite efflux pump, which belongs to the RND superfamily, is a main multi-
drug efflux system of Escherichia coli (E. coli) because of the broad resistance on various …

The inhibition of efflux pumps is a promising approach to combating multidrug-resistant
bacteria. We have developed a combined structure-and ligand-based model, using …

The structure and functioning of multidrug efflux systems provide us with a better
understanding of the transport of various antibiotics, thus giving a path for the discovery of …

Pseudomonas aeruginosa and Escherichia coli are resistant to wide range of antibiotics
rendering the treatment of infections very difficult. A main mechanism attributed to the …

Multidrug resistance pathogens causing infections and illness remain largely untreated
clinically. Efflux pumps are one of the primary processes through which bacteria develop …

The resistance-nodulation-division (RND) family efflux pumps are important in the antibiotic
resistance of Gram-negative bacteria. However, although a number of bacterial RND efflux …

The infections of multidrug-resistant bacteria, particularly the infections caused by Gram-
negative bacterial infections, are considered the main global serious health problems …