The Cryptococcus neoformans NRG1 gene was identified using gene microarrays to define
putative transcription factor genes regulated by the cyclic AMP (cAMP) signal transduction …

Bacteria are constantly subjected to stressful conditions, such as antibiotic exposure,
nutrient limitation and oxidative stress. For pathogenic bacteria, adapting to the host …

Opportunistic pathogens like Cryptococcus neoformans are constantly exposed to changing
environments, in their natural habitat as well as when encountering a human host. This …

During stress, bacteria undergo extensive physiological transformations, many of which are
coordinated by ppGpp. Although ppGpp is best known for enhancing cellular resilience by …

Most bacteria encode a large repertoire of RNA-based regulatory mechanisms. Recent
discoveries have revealed that the expression of many genes is controlled by a plethora of …

The human fungal pathogen Cryptococcus neoformans relies on a complex signaling
network for the adaptation and survival at the host temperature. Protein phosphatase …

Bacteria often have multiple copies of ribosomal RNA (rrn) genes in their genomes. The
presence of multiple rrn operons suggests an advantage to the organism, perhaps through …

The HspR protein functions as a negative regulator of chaperone and protease gene
expression in a diversity of bacteria. Here we have identified, cloned and deleted the …

The co‐ordinated regulation of heat shock proteins is critically important for the stress
response of M. tuberculosis, failure of which results in enhanced immune recognition of the …

In Escherichia coli, the rpoH gene encoding the essential heat‐shock regulator σ32, is
expressed in a complex manner. Transcription occurs from four promoters (P1, P3, P4 and …