The G protein-coupled inward rectifier K+ channel (GIRK) is activated by direct interaction
with the heterotrimeric GTP-binding protein βγ subunits (Gβγ). However, the precise role of …

G protein-gated inwardly rectifying potassium channels (GIRKs) are a family of homo-and
hetero-oligomeric K+ channels composed of different subunits (GIRK1 to 4 in mammals) …

G protein–coupled inwardly rectifying potassium channels, GIRK/Kir3. x, are gated by the
Gβγ subunits of the G protein. The molecular mechanism of gating was investigated by …

GIRK1/KGA (referred to as GIRK1) is a member of the inwardly rectifying K+ channel family
and is activated by G protein-linked receptors. The activation of this channel leads to …

G protein-activated K+ channels (GIRKs; Kir3) are activated by direct binding of Gβγ
subunits released from heterotrimeric G proteins. In native tissues, only pertussis toxin …

GIRK1 and CIR are G-protein activated inward rectifier K+ channel subunits that combine to
form the heteromultimer IKACh, the Gβγ-activated atrial K channel responsible for the vagal …

G protein‐gated inwardly‐rectifying K+ (GIRK/family 3 of inwardly‐rectifying K+) channels
are coupled to neurotransmitter action and can play important roles in modulating neuronal …

We investigated the stoichiometry of the heteromultimeric G protein-coupled inward-recitfier
K+ channel (GIRK) formed from GIRK1 and GIRK4 subunits. Multimeric GIRK constructs with …

The Xenopus laevis oocyte expression system offers the unique opportunity to
heterologously express many proteins simultaneously and to control the expression level for …

The family of G-protein-activated inward-rectifiers K+ channels presently comprise at least 3
cloned members called GIRK1, GIRK2 and GIRK3. A close structural parent of GIRK …