Investigational drugs in recent clinical trials for treatment-resistant depression
RP Garay, CA Zarate Jr, T Charpeaud… - Expert review of …, 2017 - Taylor & Francis
Introduction: The authors describe the medications for treatment-resistant depression (TRD)
in phase II/III of clinical development in the EU and USA and provide an opinion on how …
in phase II/III of clinical development in the EU and USA and provide an opinion on how …
Overview of treatment-resistant depression
CT Li - Progress in brain research, 2023 - Elsevier
Patients with major depressive disorder (MDD) often exhibit an inadequate treatment
response or failure to achieve remission following treatment with antidepressant drugs …
response or failure to achieve remission following treatment with antidepressant drugs …
Pharmacologic approaches to treatment resistant depression: a re-examination for the modern era
Importance of the field: Treatment-resistant depression (TRD) is common and debilitating.
Initial treatment is often insufficient to achieve full remission in a given depressive episode …
Initial treatment is often insufficient to achieve full remission in a given depressive episode …
[HTML][HTML] Treatment-resistant depression: recent developments and future directions
SJ Mathew - Depression and anxiety, 2008 - ncbi.nlm.nih.gov
A significant proportion of patients with major depressive disorder (MDD) fail to achieve
remission with standard antidepressant therapies, even when optimally delivered. These …
remission with standard antidepressant therapies, even when optimally delivered. These …
[HTML][HTML] Pharmacologic approaches to treatment resistant depression: evidences and personal experience
A Tundo, R de Filippis, L Proietti - World journal of psychiatry, 2015 - ncbi.nlm.nih.gov
AIM: To review evidence supporting pharmacological treatments for treatment-resistant
depression (TRD) and to discuss them according to personal clinical experience …
depression (TRD) and to discuss them according to personal clinical experience …
The hidden third: improving outcome in treatment-resistant depression
TE Schlaepfer, H Ågren, P Monteleone… - Journal of …, 2012 - journals.sagepub.com
Treatment-resistant depression (TRD) presents many challenges for both patients and
physicians. This review aims to evaluate the current status of the field of TRD and reflects the …
physicians. This review aims to evaluate the current status of the field of TRD and reflects the …
Pharmacotherapies for treatment-resistant depression: how antipsychotics fit in the rapidly evolving therapeutic landscape
One in three adults with major depressive disorder (MDD) do not experience clinically
significant improvement after multiple sequential courses of antidepressants and have …
significant improvement after multiple sequential courses of antidepressants and have …
Recent Advances in the Treatment of Treatment-Resistant Depression: A Narrative Review of Literature Published from 2018 to 2023
Abstract Purpose of Review We review recent advances in the treatment of treatment-
resistant depression (TRD), a disorder with very limited treatment options until recently. We …
resistant depression (TRD), a disorder with very limited treatment options until recently. We …
Challenging treatment-resistant major depressive disorder: a roadmap for improved therapeutics
Major depressive disorder (MDD) is associated with a significant burden and costs to the
society. As remission of depressive symptoms is achieved in only one-third of the MDD …
society. As remission of depressive symptoms is achieved in only one-third of the MDD …
Beyond monoamines-novel targets for treatment-resistant depression: a comprehensive review
JD Rosenblat, RS McIntyre, GS Alves… - Current …, 2015 - ingentaconnect.com
Major depressive disorder (MDD) is a leading cause of disability worldwide. Current first line
therapies target modulation of the monoamine system. A large variety of agents are currently …
therapies target modulation of the monoamine system. A large variety of agents are currently …