Background and Purpose Chemotherapy‐induced neuropathic pain (CINP) currently has
limited effective treatment. Although the roles of oxytocin (OXT) and the oxytocin receptor …

Objective: Oxytocin (OT) is synthesized within the paraventricular nucleus and supraoptic
nucleus of the hypothalamus. In addition to its role in uterine contraction, OT plays an …

Oxytocin (OT) plays an important role in pain modulation and antinociception in the central
nervous system. However, little is known about its peripheral effects. This study was …

Oxytocin (OXT), which is a well-known neurohypophysial hormone that is synthesized in the
paraventricular (PVN) and supraoptic nuclei (SON) of the hypothalamus, is secreted from the …

Although best known for its function in lactation, uterine contraction during parturition, and
for its role in social behaviour, the neurohormone oxytocin (OT) has also been implicated as …

Background Growing evidence in the literature shows that oxytocin (OT) has a strong spinal
anti-nociceptive action. Oxytocinergic axons originating from a subpopulation of …

Behavioral and electrophysiological data show that at the spinal level, oxytocin inhibits pain
transmission by activation of oxytocin receptors (OTRs). Canonically, OTRs are coupled to G …

Background There is increasing evidence for oxytocin as a neurotransmitter in spinal
nociceptive processes. Hypothalamic oxytocinergic neurons project to the spinal dorsal …

Use of chemotherapy drug oxaliplatin is associated with painful peripheral neuropathy that
is exacerbated by cold. Remodeling of ion channels including TRP channels in dorsal root …

Despite the high incidence of neuropathic pain, its mechanism remains unclear. Oxytocin
(OXT) is an established endogenous polypeptide produced in the supraoptic nucleus (SON) …