Activation of microglia in the spinal cord following peripheral nerve injury is critical for the
development of long-lasting pain hypersensitivity. However, it remains unclear whether …

Neuropathic pain is a prevalent and debilitating chronic disease that is characterized by
activation in glial cells in various pain‐related regions within the central nervous system …

Microglia are implicated as primarily detrimental in pain models; however, they exist across
a continuum of states that contribute to homeostasis or pathology depending on timing and …

In this review, we report existing preclinical evidence on how the CNS compartment as well
as sex affect microglia functions in health. We highlight that recent advances in …

Chronic pain is a common and devastating condition that induces well-characterized
changes in neurons and microglia. One major unanswered question is why these changes …

Microglial cells, the resident immune cells of the spinal cord, become activated in response
to peripheral nerve injury. Microglia activation contributes to the development of neuropathic …

Neuronal plasticity along the pathway for sensory transmission including the spinal cord and
cortex plays an important role in chronic pain, including inflammatory and neuropathic pain …

Peripheral nerve injury induces long-term pro-inflammatory responses in spinal cord glial
cells that facilitate neuropathic pain, but the identity of endogenous cells that resolve spinal …

While spinal microglia play a role in early stages of neuropathic pain etiology, whether they
are useful targets to reverse chronic pain at late stages remains unknown. Here, we show …

Recent studies have suggested a sexually dimorphic role of spinal glial cells in the
maintenance of mechanical hypersensitivity in rodent models of chronic pain. We have used …