Con: can comparing adherent to non-adherent patients provide useful estimates of the effect of continuous positive airway pressure?

SR Patel, AM Sawyer, DJ Gottlieb - Sleep, 2024 - academic.oup.com
The recently published technology assessment of continuous positive airway pressure
(CPAP), prepared by the Agency for Healthcare Research and Quality (AHRQ) and entitled …

Pro: comparing adherent to non-adherent patients can provide useful estimates of the effect of continuous positive airway pressure on cardiovascular outcomes

BT Keenan, UJ Magalang, G Maislin - Sleep, 2024 - academic.oup.com
Whether or not there are cardiovascular benefits of using continuous positive airway
pressure (CPAP) for patients with obstructive sleep apnea (OSA) is a foundational question …

Strategies to assess the effect of continuous positive airway pressure on long-term clinically important outcomes among patients with symptomatic obstructive sleep …

LM Donovan, CM Hoyos, RJ Kimoff… - Annals of the …, 2023 - atsjournals.org
Continuous positive airway pressure (CPAP) is the first-line treatment for obstructive sleep
apnea (OSA). Although CPAP improves symptoms (eg, daytime sleepiness), there is a lack …

Continuous positive airway pressure and adverse cardiovascular events in obstructive sleep apnea: are participants of randomized trials representative of sleep clinic …

A Reynor, N McArdle, B Shenoy, SS Dhaliwal, SC Rea… - Sleep, 2022 - academic.oup.com
Abstract Study Objectives Randomized controlled trials (RCTs) have shown no reduction in
adverse cardiovascular (CV) events in patients randomized to continuous positive airway …

Where to next for optimizing adherence in large-scale trials of continuous positive airway pressure?

AM Sawyer, DM Wallace, LF Buenaver… - Sleep medicine …, 2021 - sleep.theclinics.com
Clinical trials are defined as experiments in humans designed to evaluate the effects of
specific treatments, or exposure condition that by design reduce random error and bias. 1 …

Obstructive sleep apnea: the elephant in the cardiovascular room

JP Bakker, B Sharma, A Malhotra - Chest, 2012 - journal.chestnet.org
Despite considerable advances in the relatively young field of sleep research, the
importance of obstructive sleep apnea (OSA) remains underappreciated. A vast body of …

Continuous positive airway pressure adherence for prevention of major adverse cerebrovascular and cardiovascular events in obstructive sleep apnea

S Javaheri, MA Martinez-Garcia… - American journal of …, 2020 - atsjournals.org
Obstructive sleep apnea (OSA) is associated with major adverse cerebrovascular and
cardiovascular events (MACCEs)(1). Multiple studies have demonstrated the beneficial …

CPAP therapy for obstructive sleep apnoea: are the right questions being asked?

DJ Gottlieb - European Respiratory Journal, 2023 - Eur Respiratory Soc
Extract The recently published technology assessment of continuous positive airway
pressure (CPAP), prepared for the Agency for Healthcare Research and Quality (AHRQ) of …

[PDF][PDF] Cardiovascular events in obstructive sleep apnea-can CPAP therapy SAVE lives

B Mokhlesi, NT Ayas - N Engl J Med, 2016 - pulmcast.com
Obstructive sleep apnea is a common disorder that has been associated with an increased
risk of cardiovascular disease. 1 Continuous positive airway pressure (CPAP) is frequently …

Randomized clinical trials of cardiovascular disease in obstructive sleep apnea: understanding and overcoming bias

RD McEvoy, M Sánchez-de-la-Torre, Y Peker… - Sleep, 2021 - academic.oup.com
In their recent provocative commentary, Pack et al.[1] contend that the neutral results of
randomized controlled trials (RCTs) of continuous positive airways pressure (CPAP) for …